rTMS for Adults With Autistic Spectrum Disorder

Phase 1

• Conditions: Autism
• Interventions: Device: repetitive TMS

• Registration Number: NCT01918787
• Lead Sponsor: Chang Gung Memorial Hospital

Brief Summary

rTMS over dorsolateral prefrontal cortex is effective in reducing repetitive behaviors in adults with autistic spectrum disorder rTMS over posterior superior temporal sulcus is effective in improving social ability in adults with autistic spectrum disorder

Detailed Description

First, we will apply one session intermittent theta burst stimulation over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control with one week interval in adults with autism spectrum disorder. Second, we will apply 5 sessions intermittent theta burst stimulation within one week over dorsolateral prefrontal cortex or posterior temporal sulcus depending on the results of our first phases.

Study Timeline

• Status Verified: 2012-04
• Study Start: 2012-04
• Study First Submitted: 2013-08-02
• Study First Submitted QC: 2013-08-07
• Last Update Submitted: 2013-08-07
• Study First Posted: 2013-08-08
• Last Update Posted: 2013-08-08
• Primary Completion: 2015-04
• Study Completion: 2015-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• adults with autistic spectrum disorder

Exclusion Criteria

• schizophrenia
• bipolar affective disorder
• major depressive disorder
• any systemic disease especially epilepsy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
repetitive TMS	repetitive TMS	repetitive TMS over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control

Primary Outcome Measures

Name	Time	Method
continuous performance test	continuous performance test will be arranged before and after rTMS within one hour	continuous performance test will be arranged before and after rTMS within one hour

Secondary Outcome Measures

Name	Time	Method
Yale-Brown Obsessive Compulsive Scale	Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS within one week	Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS.

Trial Locations

Locations (1)

Chang Gung Memorial Hospital; 🇨🇳 Taoyuan, Taiwan