Evaluation of population diversity of Plasmodium falciparum isolates from children with uncomplicated infection during the adoption of artemisinin-based combination therapy in Nigeria
Not Applicable
- Conditions
- Malaria
- Registration Number
- PACTR202106708800075
- Lead Sponsor
- Kazeem Akano
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
Age
History of fever or fever (temp > 37.5oC)
Mono P. falciparum infection with asexual parasitemia of =2000 mL-1
Written informed consent, including readiness to comply with follow-up visits by the child’s parent or guardian.
Exclusion Criteria
Signs of severe malaria
severe malnutrition
History of allergy to study drug
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Responsiveness to drug treatment would be measured through Asexual parasite positivity, Parasite clearance time, Adequate clinical and parasitological response, terminal elimination halftime of asexual parasitaemia, area under curve of asexual parasitaemia, fever clearance time and anaemia recovery time.
- Secondary Outcome Measures
Name Time Method Semi-nested PCR amplification of 12 P. falciparum microsatellite loci will be used to determine the population diversity of isolates from children with uncomplicated infection.