Clinical Relevance and Prognostic Outcomes of Different Training Intensities for Cardiac Remodeling in Chronic Heart Failure.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cairo University
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Ejection fraction
Study Overview
Brief Summary
To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .
Detailed Description
Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to 60 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients with following criteria were included :
- •All patients ages were between 50 - 60 years old
- •Fractional shortening < 25% and ejection fraction < 40%
- •Sinus rhythm.
- •Heart Failure due to ischemic heart disease.
- •New York Heart Association (NYHA) class II-III.
- •Regular medical treatment.
Exclusion Criteria
- •Patients with following criteria were excluded :
- •Chronic heart failure due to other causes
- •History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension).
- •Recent acute coronary syndrome or revascularization (3 months).
- •Exercise limited by angina or peripheral arterial occlusive disease;
- •Cerebrovascular or musculoskeletal disease preventing exercise testing or training.
- •Poorly controlled or exercise-induced cardiac arrhythmias
- •Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.
Arms & Interventions
High intensity aerobic training group(HIT)
15 patients who received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.
Intervention: Aerobic exercise training (Other)
Moderate intensity aerobic training group(MIT)
15 patients who received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.
Intervention: Aerobic exercise training (Other)
Low intensity aerobic training group(LIT)
15 patients who received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months
Intervention: Aerobic exercise training (Other)
Outcomes
Primary Outcomes
Ejection fraction
Time Frame: change from baseline to after 12 weeks
represents left ventricular function measured by pulsed echocardiography
pro-brain natriuretic peptide (proBNP)
Time Frame: change from baseline to after 12 weeks
biomarker for heart failure measured by analysis of venous samples drawn
Secondary Outcomes
- Minnesota Living With Heart Failure Questionnaire (MLWHF):(change from baseline to after 12 weeks)
Investigators
Heba Ahmed Ali Abdeen
Assistant professor
Cairo University