Clinical Relevance and Prognostic Outcomes of Different Training Intensities for Cardiac Remodeling in Chronic Heart Failure.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 45
- 试验地点
- 2
- 主要终点
- Ejection fraction
研究概览
简要总结
To determine the efficacy of different aerobic exercise training intensities in patients with chronic heart failure.Forty five eligible male patients with chronic heart failure were randomly assigned into three groups( High intensity , moderate intensity and low intensity)groups .
详细描述
Forty five eligible male patients with chronic heart failure secondary to ischemic heart disease were selected from National Heart Institute heart failure outpatient clinic , their ages ranged from 50-60 years old and their ejection fraction ranged from 30-40% ,they were randomly assigned into three groups :HIT Group: received High Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months.(n=15) MIT Group: received moderate Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months. .(n=15) LIT Group: received low Intensity aerobic Training in the form of bicycle ergometer exercise for the lower limbs three times /week for three months, Before and after intervention, the following measures were obtained: Echocardiograph parameter (EF%, and left ventricular internal dimension ) , prognostic biomarkers (proBNP), and quality of life .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 60 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients with following criteria were included :
- •All patients ages were between 50 - 60 years old
- •Fractional shortening < 25% and ejection fraction < 40%
- •Sinus rhythm.
- •Heart Failure due to ischemic heart disease.
- •New York Heart Association (NYHA) class II-III.
- •Regular medical treatment.
排除标准
- •Patients with following criteria were excluded :
- •Chronic heart failure due to other causes
- •History of pulmonary disease (chronic obstructive lung disease, moderate to severe pulmonary hypertension).
- •Recent acute coronary syndrome or revascularization (3 months).
- •Exercise limited by angina or peripheral arterial occlusive disease;
- •Cerebrovascular or musculoskeletal disease preventing exercise testing or training.
- •Poorly controlled or exercise-induced cardiac arrhythmias
- •Logistic problems to attend regular exercise training sessions. Uncontrolled hypertension.
结局指标
主要结局
Ejection fraction
时间窗: change from baseline to after 12 weeks
represents left ventricular function measured by pulsed echocardiography
pro-brain natriuretic peptide (proBNP)
时间窗: change from baseline to after 12 weeks
biomarker for heart failure measured by analysis of venous samples drawn
次要结局
- Minnesota Living With Heart Failure Questionnaire (MLWHF):(change from baseline to after 12 weeks)
研究者
Heba Ahmed Ali Abdeen
Assistant professor
Cairo University