Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury
概览
- 阶段
- 不适用
- 干预措施
- Sepsis
- 疾病 / 适应症
- Sepsis
- 发起方
- Uppsala University
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Histones
- 状态
- 招募中
- 最后更新
- 3个月前
概览
简要总结
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.
研究者
Robert Frithiof
MD, PhD
Uppsala University
入排标准
入选标准
- •Patients admitted to the intensive/post operative care unit
- •with septic shock or
- •post major surgery or
- •after intoxication with a chemical compund
排除标准
- •Pregnancy or
- •Breast feeding or
- •Chronic kidney disease or
- •intoxication with nephrotoxic compund or
- •lack of informed consent
研究组 & 干预措施
Sepsis
Patients admitted to the intensive care unit with sepsis
Surgery
Patinets subjected to major surgery and then admitted to the intensive care unit
Non-inflamed
Otherwise healthy patients admitted to the intensive care unit because of intoxication.
结局指标
主要结局
Histones
时间窗: Within 1 month
Correlation between levels of histones and degree of acute kidney injury
次要结局
- Other inflammtory mediators(Within 1 month)