GUTDVT trial.

Recruiting

• Conditions: subject with suspected Deep Venous Thrombosis (DVT)

• Registration Number: NL-OMON26347
• Lead Sponsor: AMC-UvA

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Males or postmenopausal females;

2. Age between 18 and 60 years;

Exclusion Criteria

1. Smoking > 5 sig/day;

2. Premenopauzal females (due to hormonal changes);

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in fecal flora/gutmicrobiota (HITCHIP see Qin Nature 2010) analysis of 1200 known intestinal bacteria in subjects with DVT vs subjects with a clinical suspicion of DVT but the absence of this diagnosis.<br>

Secondary Outcome Measures

Name	Time	Method
Associations between gutmicrobiota changes (HITCHIP), plasma levels of coagulation (Endogenous thrombin potential) and endothelial gycocalyx metabolism (SDF sublingual imaging and plasma hyaluronan and heparansulphate by ELISA).