Peripheral Effects of Endotoxin on Insulin Resistance

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Biological: USP endotoxin

• Registration Number: NCT00929136
• Lead Sponsor: Aarhus University Hospital

Brief Summary

The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled. The hypothesis is that endotoxin will induce insulin resistance, lypolysis and proteolysis acutely.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-22
• Study First Submitted QC: 2009-06-25
• Study First Posted: 2009-06-26
• Primary Completion: 2010-05
• Study Completion: 2010-05
• Status Verified: 2010-10
• Last Update Submitted: 2010-10-01
• Last Update Posted: 2010-10-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

1. Normal health
2. 22 < BMI < 28
3. Written Informed Concent

Exclusion Criteria

1. Any disease
2. Any use of medication
3. Recent immobilization of a lower extremity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Endotoxin	USP endotoxin	-

Primary Outcome Measures

Name	Time	Method
glucose concentration	360 minutes observation

Secondary Outcome Measures

Name	Time	Method
Regional arteriovenous amino-acid balance	measured at t=180 and 360 minutes
Intra-cellular insulin signaling	measured at t=0, 120, and, 210 minutes
Regional arteriovenous lipid balance	measured at t=180 and 360 minutes

Trial Locations

Locations (1)

The Medical Research Laboratories, Dept. M, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark