Studying the effect of intravenous dexmedetomidine on spinal anaesthesia with bupivacaine. Dexmedetomidine is an alpha agonist drug known to prolong the effects of spinal anaesthesia. Bupivacaine is a local anaesthetic.

Not Applicable

Completed

• Conditions: Health Condition 1: null- American Society of Anaesthesiologists Physical Status 1 or 2

• Registration Number: CTRI/2015/01/005431
• Lead Sponsor: Manipal University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

patients undergoing elective infraumbilical or lower limb surgery in the supine position under spinal anaesthesia belonging to american society of anaesthesiologists physical status 1 or 2.

Exclusion Criteria

Patients who do not consent for subarachnoid anaesthesia

Patients with coagulopathy, hypovolaemia,

BMI > 35 kg/m2, spinal abnormalities

Chronic use of sedatives or antidepressants

History of regular alcohol consumption

Local infection over lumbar spine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
onset of analgesia at T10. <br/ ><br>highest level of analgesia. <br/ ><br>2 segment regression. <br/ ><br>recovery at S2-3. <br/ ><br>onset of motor block and recovery . <br/ ><br>sedation score.Timepoint: onset of analgesia at T10.sensory level then checked every 2 mins till <br/ ><br>highest level of analgesia achieved then every 5 mins till end of 1 hr and every 15 mins till <br/ ><br>2 segment regression, recovery. <br/ ><br>time of recovery at S2-3. <br/ ><br> motor blockade assessed using modified bromage score.onset time is when bromage score of 3 is obtained and motor recovery when modified score is 0. <br/ ><br>sedation score.sedation score recorded using ramsay sedation score every 15 mins throughout first 3 hrs.

Secondary Outcome Measures

Name	Time	Method
haemodynamic parameters-blood pressure, heart rate, saturation. other side effects like nausea, vomiting or pruritusTimepoint: BP and heart rate every 2.5 mins for first 15 mins.then 5 mins for first hour and then every 15 mins till complete recovery.