Evaluation of the effects of quercetin ointment in the prevention of radiation-induced acute proctitis in prostate cancer patients
Phase 3
Recruiting
- Conditions
- Radiation proctitis.Radiation proctitisK62.7
- Registration Number
- IRCT20120707010205N10
- Lead Sponsor
- Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
prostate cancer patients undergoing radiotherapy with a field encompassing almost whole rectum and receive a minimum dose of 4000 cGy radiation
Exclusion Criteria
Patients with history of previous radiotherapy of pelvis region
Patients receiving treatment with anti-inflammatory drugs (NSAIDS, corticosteroids)
Patients with inflammatory bowel disease (ulcerative colitis , Crohn's disease )
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Score of acute proctitis according to the staging system of the Radiation Oncology Group (RTOG). Timepoint: At the beginning of the study and then every week after the start of quercetin ointment consumption. Method of measurement: RTOG criteria to evaluate acute proctitis reaction induced by radiation therapy.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which quercetin mitigates radiation-induced acute proctitis in prostate cancer patients?
How does quercetin ointment compare to standard-of-care treatments like sucralfate in preventing acute proctitis after prostate cancer radiotherapy?
Are there specific biomarkers that can predict which prostate cancer patients will respond best to quercetin ointment for radiation-induced proctitis prevention?
What are the known adverse events associated with quercetin ointment use in the context of radiation therapy for prostate cancer?
What combination therapies or alternative compounds have shown promise in preventing radiation-induced acute proctitis alongside quercetin?