The effect of nutritional intervention on postprandial skeletal muscle microcirculation in obese subjects

Completed

Conditions: obesitas
obesity and insulin resistance

Registration Number: NL-OMON37094

Lead Sponsor: nilever

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

- Male sex
- Aged 30-70 years
- Obesity (>30 kg/m2)
- insulin resistance as fasting glucose levels >6.1 mmol/L
- Reported intense sport activities <=10 h/w
- Reported alcohol consumption <=28 units/w
- Agreeing to be informed about medically relevant personal test-results by a physician
- Signed Informed consent
- Currently not smoking and being a non-smoker for at least 3 months prior to the start of the study

Exclusion Criteria

- BMI >=40 kg/m2
- Presence of cardiovascular disease
- Presence of sudden cardiac death in a 1st degree relative at an age <50 years
- Presence of diabetes mellitus type 2
- Regular tea drinker (> 2 cups per day)29
- Prescribed medical treatment that may affect the cardiovascular system
- Reported use of any medically- or self-prescribed diet
- Reported weight loss or gain >10% during a period of 6 months prior to the study
- Subjects who participated in studies with a drug and/or nutritional intervention and without risks for carry-over effects are excluded for 1 month from participation in this study
- Reported participation in night shift work two weeks prior to the study or during the study (defined as working between midnight and 6.00 am)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Peripheral vascular resistance after a 75 gr glucose load combined with<br /><br>water/tea/beetroot juice, where vascular resistance is calculated as the<br /><br>product of blood flow as measured by venous occlusion plethysmography and<br /><br>arterial blood pressure by the Finapress (in mmHg/100 mL tissue/min). The<br /><br>area-under-the-curve of the peripheral vascular resistance in the forearm and<br /><br>leg is calculated up to 3 h after the glucose load. </p><br>

Secondary Outcome Measures