Effects of Aspirin and Low Molecular Weight Heparin in IVF Outcome.
Phase 3
- Conditions
- To Investigate the Effects of Low Dose Aspirin and Low Molecular Weight Heparin in IVF Out Come
- Interventions
- Registration Number
- NCT01924104
- Lead Sponsor
- Dr.Vandana Bansal
- Brief Summary
The purpose of the study is to determine whether low-dose aspirin and low molecular weight heparin improve the implantation and pregnancy rates in patients with repeated implantation failures in IVF cycle.
- Detailed Description
The investigators hypothesize that cotreatment of low dose aspirin \& low molecular weight heparin may improve implantation \& clinical pregnancy rates.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 400
Inclusion Criteria
- Aged between 19 to 35 years;
- Basal follicle-stimulating hormone (FSH) levels of ≤8 IU/l
- Body mass index (BMI) between 19 kg/m2 and 25 kg/m2
- Presence of both ovaries; ≥2 previous IVF failures
- Good quality embryos for transfer
- Endometrial thickness between 10 mm and 14 mm
Exclusion Criteria
- Polycystic ovary syndrome
- Endometriosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Low Molecular Weight Heparin Low molecular weight heparin Low molecular weight heparin, 2500 milli-International unit/day, subcutaneously Low dose aspirin Low dose aspirin Low dose aspirin, 75mg/day, orally Heparin & Aspirin Heparin & aspirin Heparin (40 mg/day, subcutaneously) and aspirin (70 mg/day, orally) Sodium chloride (NaCl) NaCl Equivalent volume of NaCl 0.9%, subcutaneously
- Primary Outcome Measures
Name Time Method Biological pregnancy test 14 days
- Secondary Outcome Measures
Name Time Method Fetal heart/Gestational sac 8 weeks
Trial Locations
- Locations (1)
Arpit Test Tube Baby Centre, Jeevan Jyoti Hospital & Research Centre
🇮🇳Allahabad, Uttar Pradesh, India