Efficacy and safety of oral tranexamic acid in Melasma
- Conditions
- Melasma.Chloasma
- Registration Number
- IRCT2013091914715N1
- Lead Sponsor
- Vice Chancellor for Reasearch of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion criteria : Age between 18 - 65 years old ; Symmetric distribution of melasma ; Informed consent.
Exclusion criteria : Usage of hydroquinone ,topical or oral retinoids ,topical corticosteroid ,alfa hydroxyl acids or other drugs effective to skin pigmentation 3 months prior to the study ; Usage of peeling agents 3 months prior to the study ; Laser therapy 3 months prior to the study ; Sunburn , high exposure to sunlight or solarium usage 3 months prior to the study ; Usage of oral contraceptive concurrently ; Personal or familial history of vitiligo or other pigmentation disorders ; Suspected Hypersensitivity to hydroquinone or trenaxemic acid ; Pregnancy or lactation ; History of ischemic heart disease or cerebrovascular disease ; History of coagulation disorders or deep vein thrombosis ; Usage of aspirin or Plavix.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement of pigmentation. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: MASI Score , Digital photography , Patient satisfaction.
- Secondary Outcome Measures
Name Time Method Gastrointestinal complications. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: Question of patients.;Reduce menstrual bleeding. Timepoint: Before the intervention, 1 and 3 months after the intervention and three months after discontinuation intervention. Method of measurement: Question of patients.