To understand the Effect of Karpura, Rason and Yavani(KRY) Taila in vedana and shotha of Sandhigatavata.

Phase 2

Not yet recruiting

• Conditions: Bilateral primary osteoarthritis of knee. Ayurveda Condition: SANDHIGATAVATA , (2) ICD-10 Condition: M170||Bilateral primary osteoarthritis of knee. Ayurveda Condition: SANDHIGATAVATA ,

• Registration Number: CTRI/2022/08/044949
• Lead Sponsor: Uttarakhand Ayurved University

Brief Summary

In *Ayurvedic* texts various terms such as, *Ruk, Ruja, Vedana* and *Shool* are commonly used for pain. As the word*Vedana* has been used in two sense in *Ayurveda* i.e. S*ukhatamaka Vedana* (feeling of happiness) and *Dukhatamaka Vedana* (feeling of unhappiness).*Acharaya Charaka* has mentioned the word ‘*Vedana’* is very wide which include both the healthy and diseased conditions.In A*yurveda, Vedana* word has been used in the sense of perception, knowledge, feeling and pain. So all types of pain come in the purview of *Vedana*, which are the challenges for a physician in clinic practices.Vitiated *Vata Dosha* has predominant role in manifestation of *Vedana* and *Shotha*, which are most common symptom in majority of diseases and *Sandhigatavata* (Osteoarthritis) is one of them. *Acharya Charaka* considered *Vatavyadhi* as *Maharoga*. *Sandhigatavata* is described under the *Vatavyadhies* in all *Samhita and Sangrahagrantha.**Sandhigatavata* is characterized by symptoms like *Sandhishool*(joint pain), *Shotha*(swelling), *Prasaranaakunchanyopravaruttischavedana*(painfull joint movement). It can be correlated to Osteoarthritis. Clinically it is represented as pain in joints, stiffness, tenderness, crepitus and restricted joint movements. Radiologically osteoarthritis is characterized by narrowing of joint space, osteophytic changes and deformity in joints.

Osteoarthritis is the second most common rheumatological problem and it is the most frequent joint disease with a prevalence of 22% to 39% in India. OA is more common in women than men, but the prevalence increases dramatically with age. Nearly, 45% of women over the age of 65 years have symptoms while radiological evidence is found in 70% of those over 65 years.

As mentioned in *Charaka Chikitsa Vatavyadhiadhyay*, *Taila* is the best treatment of *Vata* *Dosha*. Hence this *Taila* is selected here for breaking of *Samprapti* of *Sandhigatavata.*

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2022-08-23
• Study Start: 2022-08-29

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 1)Patient having clinical features of Osteoarthritis (Knee joint). 2)Patient between the 40.
• 70 year of age irrespective of gender. 3) Pain of mild to moderate range. 4) Cases of primary knee osteoarthritis only. 5) Patient without any anatomical deformity.

Exclusion Criteria

• 1. Patient below the 40 and above the 70 year of age.
• 2. Severe range of pain.
• 3. Patient with secondary knee osteoarthritis.
• 4. Patients having past history of RA, Gout, Psoriasis etc.
• 5. Patient suffering from any serious medical or surgical illness.
• 6. Pain due to accidental open wound injury.
• 7. Patient not willing to undergo trial.
• 8. Associated with any local fracture and fracture associated osteopathy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1) Decrease in pain intensity	3 assessment at an interval of 7 days followed by follow up period of 7 days
2) Tenderness	3 assessment at an interval of 7 days followed by follow up period of 7 days
3) Stiffness &	3 assessment at an interval of 7 days followed by follow up period of 7 days
4) Crepitus in both knee joint	3 assessment at an interval of 7 days followed by follow up period of 7 days

Secondary Outcome Measures

Name	Time	Method
1)Reduction in swelling 2)Increased in range of motion of both knee joint	3) Walking time to cover 40

Trial Locations

Locations (1)

ROOM NUMBER -1 OPD & IPD OF KAYACHIKITSA DEPARTMENT RISHIKUL CAMPUS; 🇮🇳 Hardwar, UTTARANCHAL, India

ROOM NUMBER -1 OPD & IPD OF KAYACHIKITSA DEPARTMENT RISHIKUL CAMPUS

🇮🇳Hardwar, UTTARANCHAL, India

PARTIBHA SINGH

Principal investigator

9675394313

rana.313pratibha@gmail.com