Digestion and Absorption Kinetics of Beef Consumed Alone or as Part of a Mixed-Meal: a Crossover Trial in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Digestion and absorption kinetics
研究概览
简要总结
The purpose of this study is to assess the digestion and absorption kinetics of beef consumed alone or as part in healthy adults. In a randomized, crossover design, 10 young, healthy adult males and females aged 18-35 years, will consume a meal consisting of 25 g protein from minced beef alone or as part of a mixed-meal during two separate experimental trials. The main study endpoint is the exogenous rate of amino acid appearance in response to the ingested beef over a 10-h period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 18-35 years
- •BMI between 18.5-30 kg/m2
- •Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)
- •No physical limitations (i.e., able to perform all activities associated with daily living independently)
排除标准
- •Vegan, vegetarian, or does not consume beef protein
- •Diagnosed musculoskeletal disorders
- •Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)
- •Chronic use of gastric acid-suppressing medication or anti-coagulants
- •Unstable weight over the last three months
- •Diagnosed GI tract disorders or diseases
- •Blood donation in the past 2 months
- •Females: pregnancy
研究组 & 干预措施
Beef only
干预措施: Food proteins (Dietary Supplement)
Beef in mixed-meal
干预措施: Food proteins (Dietary Supplement)
结局指标
主要结局
Digestion and absorption kinetics
时间窗: Over the 10 hour timeframe following beef ingestion
The exogenous rate of amino acid appearance in response to the ingested beef (expressed as μmol/kg/min). Based on tracer plasma amino acid concentrations over time (measured with ultra performance liquid chromatography-mass spectrometry).
次要结局
- Whole-body protein metabolism(Over the 10 hour timeframe following beef ingestion)