Determining the role of Von Willebrand factor and ADAMTS13 in the adhesion of sickled erythrocytes to endothelial cells

• Conditions: hereditary anemia; sickle cell disease; 10038158; 10027664

• Registration Number: NL-OMON32743
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

Adult sickle cell patients with HbSS or HbS*0 als genotype

Exclusion Criteria

Therapeutic intervention with hydroxyurea (Hydrea), with an extra exclusion criterium for the non-transfused patients that they have not been transfused in the last 4 months.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main study parameter is the amount and percentage of adhesion as compared to a<br /><br>baseline measurement with normal erythrocytes. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-</p><br>