Minimum Effective Volume of Lidocaine-Bupivacaine for Ultrasound-Guided Subgluteal Sciatic Nerve Block

McGill University Health Centre/Research Institute of the McGill University Health Centre1 site in 1 country60 target enrollmentMarch 2016

ConditionsInjuries to the Ankle and Foot

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Injuries to the Ankle and Foot
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Enrollment: 60
Locations: 1
Primary Endpoint: success rate
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to determine the minimum effective volume of LA in 90 % of patients (MEV90) required for US-guided subgluteal sciatic nerve block.

Detailed Description

The aim of this study is to determine the minimum effective volume of LA in 90 % of patients (MEV90) required for US-guided subgluteal sciatic nerve block. Success rate is defined as a minimal composite score of 6 points (out of 8 points) at 30 minutes.

Registry

clinicaltrials.gov

Start Date

March 2016

End Date

December 2016

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Responsible Party

Principal Investigator

De Tran

Associate Professor

McGill University Health Centre/Research Institute of the McGill University Health Centre

Eligibility Criteria

Inclusion Criteria

•age between 18 and 75 years
•American Society of Anesthesiologists classification 1-3
•body mass index between 20 and 35

Exclusion Criteria

•adults who are unable to give their own consent
•pre-existing neuropathy (assessed by history and physical examination)
•coagulopathy (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. platelets≤ 100, International Normalized Ratio≥ 1.4 or partial prothrombin time ≥ 50)
•renal failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. creatinine ≥ 100)
•hepatic failure (assessed by history and physical examination and, if deemed clinically necessary, by blood work up i.e. transaminases ≥ 100)
•allergy to LA
•pregnancy
•prior surgery in the subgluteal region
•chronic pain syndromes requiring opioid intake at home