The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block
Overview
- Phase
- Not Applicable
- Intervention
- Ropivacaine
- Conditions
- Supraclavicular Brachial Plexus Block
- Sponsor
- Huazhong University of Science and Technology
- Enrollment
- 114
- Locations
- 1
- Primary Endpoint
- The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The aim of this study is to determine the minimum effective volume of local anesthetic (ropivacaine 0.275% and 0.325%) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEV90) in young group (18-40 years) and in middle aged group (40-65 years) of patients scheduled for elective surgery of one upper limb distal to the shoulder.
Detailed Description
The study is based on biased coin design, and the volume of LA for the next patient is determined by the result of the last one. In the case of block failure, the volume will be increased by 2ml. Conversely, block success will result in either a reduction in volume by 2ml (probability 11%) or no change in volume (probability 89%). A blinded assistant will assess sensory and motor blockade in each nerve territory ( the median, radial, ulnar and musculocutaneous nerves) at 10-min intervals up to 30 min after completion of the block. Finally, MEV90 is calculated by isotonic regression.
Investigators
Fang Gang
Dr.
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- •age between 18 and 65 years
- •body mass index between 18 and 35kg/m2
Exclusion Criteria
- •inability to consent to the study
- •allergy to local anesthetics
- •preexisting neuropathy or coagulopathy
- •prior surgery in the supraclavicular region
Arms & Interventions
middle aged group
brachial plexus block with ropivacaine 0.275%, MEV90 for USG-SCB
Intervention: Ropivacaine
young group
brachial plexus block with ropivacaine 0.325%, MEV90 for USG-SCB
Intervention: Ropivacaine
Outcomes
Primary Outcomes
The Minimum Effective Volume of Ropivacaine in Ultrasound-guided Supraclavicular Block
Time Frame: up to 6 months
The Minimum Effective Volume (MEV) of Ropivacaine in Ultrasound-guided Supraclavicular Block is based on 55 measurements in 55 patients (secondary outcome measure: block success). MEV is determined by biased coin design method when all patients have been tested in the study.