Median Effective Concentration of Ropivacaine for Ultrasound-guided Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diabetic Foot
- Sponsor
- Seoul National University Hospital
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Median effective anesthetic concentration 90 (MEAC 90)
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study was to determine the minimum effective dose of a local anesthetic for proper anesthesia for popliteal sciatic nerve block under ultrasound guidance in patients undergoing surgery for diabetic foot disease.
Detailed Description
Unlike general patients, patients with diabetic foot disease often have diabetic neuropathy and thus have increased sensitivity to local anesthetics. Therefore, when performing sciatic nerve block, it is essential to properly adjust the dose to prevent neurotoxicity and delay in recovery due to local anesthetics. If the appropriate effective dose of local anesthetic for sciatic nerve block is found in patients with diabetic foot through this study, it is expected that it will be a useful basis for establishing a safe anesthetic method in the case of diabetic foot surgery.
Investigators
Seokha Yoo
Clinical Assistant Professor
Seoul National University Hospital
Eligibility Criteria
Inclusion Criteria
- •Adult patients who can be operated under popliteal sciatic nerve block among patients undergoing surgery for diabetic foot disease
Exclusion Criteria
- •Infection of the popliteal region
- •Severe coagulation abnormality
- •Allergic reaction or hypersensitivity to local anesthetics
- •Neurological abnormalities other than diabetic neuropathy in the lower extremity of the operation site
- •When it is impossible to evaluate sensory blockage and motor blockage
- •When the patient refuses
Outcomes
Primary Outcomes
Median effective anesthetic concentration 90 (MEAC 90)
Time Frame: within 30 minutes from the popliteal sciatic block
Concentration of ropivacaine required for successful sciatic nerve block in 90% of all patients
Secondary Outcomes
- Motor block onset time(within 30 minutes from the popliteal sciatic block)
- Block duration(within 24 hours post-operatively)
- Any adverse events(within 24 hours post-operatively)
- Time to first rescue analgesia(within 24 hours post-operatively)
- Median effective anesthetic concentration 50 (MEAC 50)(within 30 minutes from the popliteal sciatic block)
- Sensory block onset time(within 30 minutes from the popliteal sciatic block)