The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Minimum Effective Concentration of Local Anesthetic
- Sponsor
- Huazhong University of Science and Technology
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The aim of this study is to determine the minimum effective concentration of local anesthetic (ropivacaine 40mL) required to produce an effective double-injection USG-SCB for surgical anesthesia in 90% of patients (MEC90) in young group (18-40 years) and in middle aged group (40-65 years) of patients scheduled for elective surgery of one upper limb distal to the shoulder.
Detailed Description
The study is based on biased coin design, and the concentration of LA for the next patient is determined by the result of the last one. In the case of block failure, the concentration will be increased by 0.025%. Conversely, block success will result in either a reduction in concentration by 0.025% (probability 11%) or no change in concentration (probability 89%). A blinded assistant will assess sensory and motor blockade in each nerve territory ( the median, radial, ulnar and musculocutaneous nerves) at 10-min intervals up to 30 min after completion of the block. Finally, MEC90 is calculated by isotonic regression.
Investigators
Fang Gang
Dr.
Huazhong University of Science and Technology
Eligibility Criteria
Inclusion Criteria
- •age between 18 and 65 years
- •body mass index between 18 and 35kg/m2
Exclusion Criteria
- •inability to consent to the study
- •allergy to local anesthetics
- •preexisting neuropathy or coagulopathy
- •prior surgery in the supraclavicular region
Outcomes
Primary Outcomes
The Minimum Effective Concentration of Ropivacaine in Ultrasound-guided Supraclavicular Block
Time Frame: up to 6 months
The Minimum Effective Concentration (MEC) of Ropivacaine in Ultrasound-guided Supraclavicular Block is based on 60 measurements in 60 patients (secondary outcome measure: block success). MEC is determined by biased coin design method when all patients have been tested in the study.
Secondary Outcomes
- Block success(up to 30 minutes after nerve block is performed)