The Cardiovascular Effects of Nitrogen Dioxide Exposure

Not Applicable

Completed

• Conditions: Endothelial Dysfunction
• Interventions: Procedure: Forearm Vascular Study

• Registration Number: NCT00774514
• Lead Sponsor: University of Edinburgh

Brief Summary

Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived particulate matter derived from traffic sources. It has been demonstrated that inhalation of diesel exhaust impairs vascular vasomotor tone and endogenous fibrinolysis. Recent studies using an inline retrofit particle trap to reduce the particulate component of exhaust have shown that filtering particles leads to a reversal of the endothelial dysfunction seen after diesel exhaust exposure, and have even suggested an augmentation of vascular function. This raises the question of the cardiovascular effects of the gaseous pollutants, the most abundant of which is nitrogen dioxide. In this study we plan to investigate the cardiovascular effects of nitrogen dioxide exposure.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-10-16
• Study First Submitted QC: 2008-10-16
• Study First Posted: 2008-10-17
• Primary Completion: 2008-12
• Study Completion: 2008-12
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-08
• Last Update Posted: 2009-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Healthy male volunteers

Exclusion Criteria

• Current smokers
• Significant occupational exposure to air pollution
• Regular medication use
• Intercurrent illness

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Air exposure	Forearm Vascular Study	1 hour exposure to filtered air during intermittent exercise
NO2 exposure	Forearm Vascular Study	1 hour exposure to nitrogen dioxide at 4ppm during intermittent exercise

Primary Outcome Measures

Name	Time	Method
Forearm blood flow measured by venous occlusion plethysmography in response to intraarterial vasodilators (acetylcholine, sodium nitroprusside, bradykinin and verapamil)	4-6 hours after exposure

Secondary Outcome Measures

Name	Time	Method
Plasma t-PA concentrations after infusion of bradykinin	During forearm study
Exhaled nitric oxide	4-6 hours after exposure

Trial Locations

Locations (1)

Umeå University; 🇸🇪 Umeå, Sweden