CTRI/2015/10/006285已完成未知
EPINEPHRINE vs DOPAMINE AS FIRST LINE VASOACTIVE DRUG IN NEONATAL SEPTIC SHOCK: A DOUBLE BLIND RANDOMIZED CONTROLLED TRIA
PGIMERChandigarh0 个研究点目标入组 64 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 64
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •a.Shock diagnosed as hypotension ( <5th centile
- •according to Zubrowâ??s charts)48
- •b.Presence of fluid refractory shock. Fluid
- •refractory shock5,10,40 is defined as the
- •presence of signs of septic shock despite fluid
- •challenge (two boluses of 10 ml / kg each given
- •over 15-20 minutes each).
- •c.Peripheral circulatory dysfunction - Two of the
- •Oliguria: urine output < 0.5 ml /kg / hr.
- •Prolonged capillary refill: >4 sec.
- •Core to peripheral temperature gap > 3ï?° C
- •Unexplained metabolic acidosis: base
- •deficit > 5.0 mEq / L.
- •Increased arterial lactate > 2 times upper
- •limit of normal
排除标准
- •1.Presence of lethal congenital malformations.
- •2.Hypovolemic shock- setting of blood loss (ante
- •partum hemorrhage, obvious blood loss, clinical
- •features of dehydration ie setting of fluid
- •loss and / or depressed anterior fontanel,
- •sunken eyeballs.
- •3.Baby diagnosed or suspected to have Duct
- •dependent congenital heart disease.
- •4.Suspected or proven Cardiogenic shock- setting
- •of Lt to Rt shunt with no evidence of sepsis
- •5.Shock in VLBW Babies in first 12 hrs of life,
- •who donâ??t have settings of sepsis.
- •6.Severe birth asphyxia with evidence of HIE II or
- •III in term / near-term neonates of 36 weeks
- •(Sarnat staging) or moderate / severe
- •encephalopathy (Levene classification) in
- •preterm neonates of < 36 weeks.
- •7.Shock in VLBW Babies in first 12 hrs of life,
- •who donâ??t have settings of sepsis
- •8.Baby already on vasopressors.
- •9.Study investigator to perform
- •echocardiography is not available
研究者
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