A Phase 1b Dose-escalation Study Evaluating the Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of GS-9901 in Subjects With Relapsed or Refractory Follicular Lymphoma, Marginal Zone Lymphoma, Chronic Lymphocytic Leukemia, or Small Lymphocytic Lymphoma
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 7
- 试验地点
- 6
- 主要终点
- Occurrence of adverse events (AEs) and clinical laboratory abnormalities defined as dose limiting toxicities (DLTs)
研究概览
简要总结
This study will evaluate the safety and tolerability of GS-9901 monotherapy in adults with follicular lymphoma (FL), marginal zone lymphoma (MZL), chronic lymphocytic leukemia (CLL), or small lymphocytic lymphoma (SLL). The study will also characterize the pharmacokinetic (PK) profile of GS-9901, determine the appropriate dosing regimen of GS-9901 for use in future clinical trials, and to evaluate the efficacy of GS-9901 monotherapy in adults with FL, MZL, CLL, or SLL.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of FL, MZL, SLL, or CLL (meeting International Workshop on CLL [IWCLL] Criteria, 2008) as documented by medical records and with histology based on criteria established by the World Health Organization
- •FL Grades 1, 2, or 3a
- •SLL with absolute lymphocyte count of < 5 x 10^9/L at initial diagnosis
- •MZL (splenic, nodal, or extra-nodal)
- •Prior treatment for FL or CLL/SLL with ≥ 1 prior chemotherapy-based or immunotherapy-based regimen with no approved therapies available
- •Presence of radiographically measurable lymphadenopathy or extra nodal lymphoid malignancy
- •All acute toxic effects of any prior antitumor therapy resolved to Grade ≤1 before the start of study therapy (with the exception of alopecia [Grade 1 or 2 permitted], or bone marrow parameters [any of Grade 1, 2, or 3 permitted)
- •Eastern Cooperative Oncology Group (ECOG) ≤ 2
- •Able to provide written informed consent
排除标准
- •History of lymphoid malignancy other than FL, MZL, SLL, or CLL
- •History of myelodysplastic syndrome
- •History of a non-lymphoid malignancy except for the following: adequately treated local basal cell or squamous cell carcinoma of the skin, cervical carcinoma in situ, superficial bladder cancer, asymptomatic prostate cancer without known metastatic disease and with no requirement for therapy or requiring only hormonal therapy and with normal prostate-specific antigen for ≥ 1 year prior to start of study therapy, or any other cancer that has been in complete remission for ≥ 5 years
- •Evidence of ongoing systemic bacterial, fungal, or viral infection at the time of start of study therapy
- •Ongoing drug-induced pneumonitis
- •Ongoing inflammatory bowel disease
- •History of prior allogeneic bone marrow progenitor cell or solid organ transplantation
- •History of prior therapy with any inhibitor of serine/threonine kinase (AKT), Bruton tyrosine kinase (BTK), Janus kinase (JAK), mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase (PI3K), or spleen tyrosine kinase (SYK)
- •Ongoing immunosuppressive therapy, including systemic corticosteroids for treatment of lymphoid malignancy
研究组 & 干预措施
GS-9901
Participants will receive one of 6 escalating doses of GS-9901 once daily until unacceptable toxicity, substantial noncompliance, disease progression, pregnancy, initiation of another anti-cancer or experimental therapy, or other protocol-specified reasons for GS-9901 discontinuation.
干预措施: GS-9901 (Drug)
结局指标
主要结局
Occurrence of adverse events (AEs) and clinical laboratory abnormalities defined as dose limiting toxicities (DLTs)
时间窗: Up to 28 days
Overall safety profile will be characterized by number of participants experiencing adverse events or laboratory abnormalities.
次要结局
- Occurrence of AEs and clinical laboratory abnormalities not defined as DLTs(Up to 2 years)
- Overall response rate(Up to 2 years)
- Progression-free survival(Up to 2 years)
- Duration of response(Up to 2 years)
- PK profile of GS-9901(Predose and 0.5, 1, 1.5, 2, 3, 4, 6, and 24 hours postdose on Days 1 and 15; predose and 1.5 hours postdose on Days 29, 43, 85, and 169)