Effect of Pistacia atlantica resin in the treatment of knee arthrosis

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 100

Inclusion Criteria

male or female patients with 1 or 2 knees osteoarthritis according to the American College of Rheumatology criteria after physical examination and knee joint radiography, age of 40 to 85 years, flare of the disease after oral non-steroidal anti-inflammatory drug or acetaminophen discontinuation which have been used at least 3 days a week during the past month (flare means increase of at least 2 scores in the total pain subscale score in the beginning of the study.), Western Ontario and McMaster Universities (WOMAC) pain subscale index at least 9 out of 20 in the beginning of the study. Exclusion criteria: secondary osteoarthritis (due to a definite disease); arthroscopy; surgery; knee joint injection during the past 6 months; history of knee replacement surgery; any serious systemic disease (such as concomitant infections, cardiovascular, hepatic and renal diseases); any other chronic inflammatory disease; intake of any other supplement except multivitamin; intake of non-steroidal anti-inflammatory drugs; intake of any steroidal drug, skeletal muscle relaxing drug, anti-depressant drugs, glucosamine, chondroitin, tramadol and topical analgesic drugs like capsaicin and generally any analgesic drug; any history of alcohol, drug and narcotics abuse; skin disease at the site of topical use of the oleoresin or placebo (knee); having fibromyalgia and other debilitating diseases affecting the knee; pregnant women; women planning pregnancy; lactating women.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Extent of arthritis. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of joint pain. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of joint stiffness. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.;Extent of physical function. Timepoint: Before intervention and 1 month after intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index questionnaire.

Secondary Outcome Measures

Name	Time	Method
Dose of acetaminophen. Timepoint: Before intervention and 1 month after intervention. Method of measurement: Daily recording of the acetaminophen dose by the patient.