Phenytoin in the Healing of Clean Surgical Wounds
- Registration Number
- NCT02413658
- Lead Sponsor
- Children's Surgical Center, Cambodia
- Brief Summary
The purpose of this study is to investigate the potential healing properties of phenytoin.
The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial of topical phenytoin against current best clinical practice. The investigators aim to demonstrate a dose dependent effect. The investigators hypothesis, based on previous clinical experience at our center and on current available literature, that phenytoin will reduce wound healing time.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Undergoing split thickness skin graft during trial time period at Children's Surgical Centre
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control Sugar solution Dressings of best current clinical practice, sugar solution. Phenytoin 1 Phenytoin Dressings using phenytoin solution 20mg/ml Phenytoin 2 Phenytoin Dressings using phenytoin solution 40mg/ml
- Primary Outcome Measures
Name Time Method Percentage rate of re-epithelialization Participants will be followed for the duration of hospital stay, an expected average of 20 days Pictures taken of wound site every other day will be analysed using imaging software for size of wound. Percentage rate will be calculated from this.
Appearance of infection Participants will be followed for the duration of hospital stay, an expected average of 20 days Pictures taken of wound site every other day will be analysed using imaging software and the Southampton wound grading scale
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Surgical Centre
🇰ðŸ‡Phnom Penh, Cambodia