Effect of the Stellate Ganglion Block on the Retinal Microcirculation

Recruiting

• Conditions: OCTA; Severe Brain Injury; Subarachnoid Hemorrhage; Intracerebral Hemorrhage

• Registration Number: NCT06797752
• Lead Sponsor: University of Texas Southwestern Medical Center

Brief Summary

Surges in the sympathetic nervous system occur at the ictus of a variety of neurological critical illnesses including intracranial hemorrhage and ischemic stroke. It is hypothesized that these exaggerated increases in sympathetic nervous activity produce maladaptations that promote secondary brain injury. One of these possible mechanisms include diffuse vasospasm that cause cerebral ischemia. Hence, methods to abrogate the sympathetic nervous system in this context are under active investigation. One possible method is the regional anesthesia technique of the stellate ganglion nerve block, which is ordinarily used for complex regional pain syndrome, but has been shown to reduce cerebral sympathetic activity and reduces vasospasm in patients with subarachnoid hemorrhage. However, its effect on the microcirculation is not clear. Hence, we propose to study patients receiving the stellate ganglion nerve block as part of their standard medical care and to image their retinal microcirculation before and after the procedure using Optical Coherence Tomography Angiography (OCTA).

Detailed Description

Not available

Study Timeline

• Study Start: 2024-10-07
• Study First Submitted: 2024-12-21
• Status Verified: 2025-01
• Study First Submitted QC: 2025-01-27
• Last Update Submitted: 2025-01-27
• Study First Posted: 2025-01-28
• Last Update Posted: 2025-01-28
• Primary Completion: 2025-10-07
• Study Completion: 2025-10-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Age 18 years or older
• Patients receiving the stellate ganglion nerve block for an approved indication, e.g. complex regional pain syndrome

Exclusion Criteria

• Pregnancy
• Non-English speaking
• Temporary or permanent physical limitation that renders the patient unable to sit up and look inside OCTA device

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vascular and Perfusion Density	One day	Quantitative measure of retinal microperfusion

Trial Locations

Locations (1)

UT Southwestern Medical Center; 🇺🇸 Dallas, Texas, United States