HMGB1 in ICU-survivors
Completed
- Conditions
- SepsisCognitive Impairment
- Registration Number
- NCT02914756
- Lead Sponsor
- Karolinska University Hospital
- Brief Summary
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis?
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Male/Female age 18-17
- Expected ICU-stay more than 24 hours
Exclusion Criteria
- Dont understand the language
- Substance abuse, alcohol or drugs
- Blind, deaf or suffering from aphasia
- Ongoing psychiatric illness or psychopharmacological treatment
- Suffering from dementia och mentally impaired
- Structured brain damage or meningitis
- Palliative Care
- ICU-treated for more than 48 hours
- Transferred from other ICU
- Being treated with ECMO
- Not having residency in Stockholm
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Is HMGB1 elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? 2 years Do patients recovering from severe sepsis/septic shock suffer from cognitive impairment and is such impairment associated with prolonged HMGB1 levels in plasma? Is there a difference from patients recovering from critical illness without prior sepsis? 4 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dept of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital
🇸🇪Stockholm, Sweden