ong-term sequelae after severe sepsis: cognitive impairments and structural changes in the brain, an MRI study
Recruiting
- Conditions
- Other sepsisSeptic shockA41R57.2
- Registration Number
- DRKS00005484
- Lead Sponsor
- Integriertes Forschungs- und Behandlungszentrum (IFB) Sepsis und Sepsisfolgen: Center for Sepsis Control and Care (CSCC); Universitätsklinikum Jena
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Sepsis patients:
Survivors of severe sepsis/ septic shock; male and female adults aged between 18-65 years; Written informed consent; former sepsis patients with an IQCODE > 2,29; Former sepsis patients who requested help of the German Sepsis Aid between 2011 and 2013
Normal healthy controls:
male and female adults aged between 18-65 years; Written informed consent
Exclusion Criteria
stroke or other severe CNS disorders; epilepsy; cardiac pacemaker, defibrillator and other electromagnetic devices; Liver cirrhosis; amaurosis; current intake of neuroleptics/ antidepressants; acute claustrophobia; pregnancy; participation in another study
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method characterization of structural changes in the brain via fractional anisotropy; voxel based morphometry of the amygdala/ hippocampus
- Secondary Outcome Measures
Name Time Method Correlation between cognitive outcomes (TAP/ DemTect) and MEG parameters; Structural changes in the brain in terms of fiber damages; change of functional connectivity in former sepsis patients