Study of the effects of therapeutic plasmapheresis in comparison with corticosteroid therapy on the immune system of MS patients
Not Applicable
- Conditions
- Multiple sclerosis.Multiple sclerosis
- Registration Number
- IRCT2012072110349N1
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
1- Relapsing-Remiting Multiple Sclerosis (RR-MS) patients with severe relapses,
2- Indicated for corticoestroid therapy, Or indicated for Plasma Exchange therapy
3- Satisfaction of patients to participate in the study
4- Not reception of any Immunomodulatory treatment atleast in last 2 months
5- Having more than 15 and less than 50 years age
Exclusion criteria:
1-Those patients who dont complete the course of therapy with any reason
2- Those patients who have not any of the above mentioned including criteria
3- Patients who have other types of MS disease apart from RR-MS
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Regulatory T lymphocytes frequency. Timepoint: Befor the first and at the end of last session of treatment. Method of measurement: Flowcytometry.;Th17 lymphocytes frequency. Timepoint: before the first and at the end of last session of treatment. Method of measurement: Flowcytometry.
- Secondary Outcome Measures
Name Time Method EDSS. Timepoint: 1-2 weeks after last session of Plasma Exchange. Method of measurement: EDSS table ( performs by a Neurologist ).