Improvement of pain and quality of life in patients with sickle cell disease with overnight oxygen therapy or auto-adjusting positive airway pressure (APAP)

Not Applicable

Completed

• Conditions: Sickle Cell Disease; Haematological Disorders; Sickle-cell anaemia without crisis

• Registration Number: ISRCTN46078697
• Lead Sponsor: niversity Hospital Southampton NHS Foundation Trust (UK)

Brief Summary

2015 protocol in http://www.ncbi.nlm.nih.gov/pubmed/26303626 2019 results in https://pubmed.ncbi.nlm.nih.gov/31319882/ (added 04/03/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-07-18
• Study Completion: 2014-12-01
• Last Update Posted: 15 March 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

1. Age over 8 years
2. Informed consent with assent in accordance with the institutional policies (UK ethical committee) and European or US Federal guidelines
3. Sickle cell haemoglobin (HbSS) diagnosed by standard techniques
4. Able to speak and understand English
5. Patient or parent/guardian able to use smart phone

Exclusion Criteria

1. Patient already on overnight respiratory support or has used it in the past
2. Hospital admission for acute sickle complication within the past 1 month
3. Patient with > 6 admissions for acute sickle complications within the past 12 months
4. Existing Respiratory Failure
5. Decompensated Cardiac Failure
6. History of Severe Epistaxis
7. Transsphenoidal

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient feasibility, acceptability and preference will be explored using qualitative interviews