A Genetic Study for Alzheimer Dementia: Case-control Study

MinYoung Kim, MD, PhD0 sites20 target enrollmentMarch 26, 2024

Overview

The purpose of this study is to find out the difference in genetic test results between Alzheimer's dementia patients and healthy subjects.

The investigators want to identify genes that are importantly related to Alzheimer's dementia.

Registry

clinicaltrials.gov

Start Date

March 26, 2024

End Date

December 31, 2026

Last Updated

2 years ago

Study Type

Observational

Sex

All

Sponsor

MinYoung Kim, MD, PhD

Responsible Party

Sponsor Investigator

Principal Investigator

MinYoung Kim, MD, PhD

Sponsor-Investigator

Bundang CHA Hospital

•Alzheimer's dementia patient
•Adult patients over 60 years old
•Patients with a Alzheimer's dementia patient
•Total Korean version of mini-mental state examination (K-MMSE) score less than 24
•Total Clinical Dementia Rating (CDR) over 0.5
•Inclusion Criteria: healthy subjects
•Adult healthy over 60 years old
•Total Korean version of mini-mental state examination (K-MMSE) over 24
•Total Clinical Dementia Rating (CDR) is 0

•Those with severe medical conditions such as unstable conditions of the cardiovascular system, digestive system, respiratory system, endocrine system, etc., who are in poor general condition
•In the case of a person with impaired consent (MMSE less than 10 points), if not accompanied by a guardian
•Other cases where the researcher determines that participation in this clinical trial is not appropriate (Patients who are participating in other studies or have participated in other studies within the past 30 days can also participate in this study.)

genetic analysis

Time Frame: Baseline

5cc blood collection for genetic testing

Measurement of Korean version of mini-mental state examination (K-MMSE)(screening, Baseline)
Measurement of Geriatric Depression Scale (GDSd)(Baseline)
Measurement of Clinical Dementia Rating (CDR)(screening, Baseline)