Preimplant Site Augmentation Using MPM Versus Autogenous Bone Graft

Not Applicable

• Conditions: Bone Resorption
• Interventions: Other: Autogenous bone graft (gold standard).; Other: Mineralized plasmatic matrix (MPM).

• Registration Number: NCT03007069
• Lead Sponsor: Cairo University

Brief Summary

Using growth factors obtained from patient's venous blood mixed with particulate autogenous bone the study compares bone gain by implant with gold standards.

Detailed Description

To study the effectiveness of MPM in ridge augmentation with implant insertion compared with autogenous bone graft.

-PICO-

Population (P): Patients with defective maxillary alveolar ridge requiring implant insertion.

Intervention (I): Ridge augmentation with MPM.

Comparator (C): Autogenous bone graft.

Outcome (O): Patient satisfaction - Implant stability.

Basic Information
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Recruitment & Eligibility
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Study & Design

Study Timeline

• Status Verified: 2016-12
• Study First Submitted: 2016-12-25
• Study First Submitted QC: 2016-12-30
• Last Update Submitted: 2016-12-30
• Study Start: 2017-01
• Study First Posted: 2017-01-02
• Last Update Posted: 2017-01-02
• Primary Completion: 2017-09
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Medically free patients.
2. Evaluated bone height on CBCT to be (0-4 mm buccal bone dehiscence) and width (not less than 4.5 mm)
3. Patients with Anterior maxillary defective partially edentulous ridge.
4. Age between 18 and 40 years.
5. Both sexes.
6. Patients physically able to tolerate surgical and restorative procedures.
7. Patients with an opposing tooth to the pre-implant site.
8. Good oral hygiene.
9. Highly motivated patients.

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Exclusion Criteria

1. Patients allergic to local anesthetic agent.
2. Pregnant or lactating females.
3. Presence of any pathosis in the pre-implant site.
4. Presence of any mucosal disease.
5. Presence of parafunctional habits.
6. History of oral radiotherapy.
7. History of prolonged steroids use.
8. Psychological disorders.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Autogenous bone graft (Gold Standard).	Autogenous bone graft (gold standard).	Patients with defective maxillary alveolar ridges requiring implant insertion will have Autogenous bone graft (Gold standard) and collagen membrane to be used for bone augmentation around exposed threads of inserted dental implants.
MPM Augmentation.	Mineralized plasmatic matrix (MPM).	Mineralized plasmatic matrix (MPM) to be used without collagen membrane to augment the defect in the maxillary bone and cover the exposed threads of the dental implants.

Primary Outcome Measures

Name	Time	Method
Patient Satisfaction regarding esthetic results , outcome will be measure using questionnaire.	5 months

Secondary Outcome Measures

Name	Time	Method
Stability of dental implants , this will be measured using Ostell device in ISQ units.	5 months.