Research to the possible assciation between Chlamydia infection and the development of biliary atresia.
Recruiting
- Conditions
- Extrahepatic Biliary Atresia, Chlamydia infection
- Registration Number
- NL-OMON28565
- Lead Sponsor
- Paul Fockens, MD, PhD Department of Gastroenterology and HepatologyAcademic Medical CenterThe Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
• Biopsy proven biliary atresia
• Underwent Kasai operation
Exclusion Criteria
• Patients with embryonic biliary atresia
• Older then 12 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The presence of Chlamydia IgA antibody in serum of Dutch patients with biliary atresia, compared to the control group. The presence of Chlamydia in liver tissue (liver biopsy and fibrotic remnant obtained during Kasai operation) of BA patients as compared to controls, examined by PCR as well as Chlamydia-specific staining by immunohistochemistry.
- Secondary Outcome Measures
Name Time Method The presence of Chlamydia IgA antibody in serum of mothers of patients with biliary atresia, compared to the presence of Chlamydia IgA antibody in serum of mothers of the control group and the presence of Chlamydia IgA antibody in the general population.