Repetitive Transcranial Magnetic Stimulation in the Treatment of Primary Progressive Aphasia: A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Primary Progressive Aphasia
- Sponsor
- Peking Union Medical College Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Western Aphasia Battery (WAB) Word recognition
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Primary Progressive Aphasia (PPA) is a neurodegenerative disease in which language function is gradually and progressively impaired. Patients will eventually be disabled in communication and have cognition deficits, which put a heavy burden not only on their families but also on the whole society. However, no effective treatment for PPA has been explored so far. The current clinical randomized trial is to study the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of PPA. Also, multi-modality of neuroimaging techniques, such as functional MRI and PET will be used to investigate brain network changing in this procedure.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of PPA
Exclusion Criteria
- •Scored below 15 on the mini-mental state exam (MMSE)
- •history of seizures or unexplained loss of consciousness
- •pregnancy
- •surgical breach of the skull
- •MRI contraindication
Outcomes
Primary Outcomes
Western Aphasia Battery (WAB) Word recognition
Time Frame: 1 month, 3 months and 6 months after the treatment
Assessment of the reading. Scores range from 0 to 60. Higher scores means better outcome.
Boston naming test evaluation
Time Frame: 1 month, 3 months and 6 months after the treatment
Assessment of the language production. Scores range from 0 to 30. Higher scores means better outcome.
Western Aphasia Battery (WAB) Repetition
Time Frame: 1 month, 3 months and 6 months after the treatment
Assessment of the repetition ability. Scores range from 0 to 100. Higher scores means better outcome.
Western Aphasia Battery (WAB) Speech fluency
Time Frame: 1 month, 3 months and 6 months after the treatment
Assessment of the language production. Scores range from 0 to 20. Higher scores means better outcome.
Syntax comprehension part of Bilingual aphasia test (Standard Modern Chinese Version)
Time Frame: 1 month, 3 months and 6 months after the treatment
Assessment of the grammar ability. Scores range from 0 to 50. Higher scores means better outcome.
Secondary Outcomes
- functional connectivity map (FC map)(1 month, 3 months and 6 months after the treatment)
- Standardized Uptake Value (SUV)(1 month, 3 months and 6 months after the treatment)