Transcranial Magnetic Stimulation in Primary Progressive Aphasia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Primary Progressive Aphasia
- Sponsor
- Hospital San Carlos, Madrid
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Changes in reading
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical variants are currently recorgnized (nonfluent, semantic, and logopenic PPA). Nowadays, there are no effective treatments for this disorder.
Transcranial Magnetic Stimulation (TMS) is a technique based on the principle of electromagnetic induction of an electric field in the brain. It has been used as a non-invasive therapy in different disorders, such as depression, bipolar disorder, Parkinson's disease, and in the rehabilitation of post-stroke aphasia. Recent studies have shown how repetitive TMS improved language characteristics in Alzheimer's disease, and there are initial data in patients with PPA.
This research project investigates the effect of repetitive TMS in patients with PPA. Investigators will perform a personalized TMS treatment for each patient (brain region, type of stimulation/inhibition, etc.), according to the specific characteristics of each patient and with the final aim to generate a computational model.
Investigators
Jordi A Matias-Guiu
Principal Investigator. PhD MD
Hospital San Carlos, Madrid
Eligibility Criteria
Inclusion Criteria
- •Must be clinically diagnosed of PPA according to current diagnostic criteria (Gorno-Tempini et al. 2011) with PET-FDG confirmation.
- •Clinical Dementia Rating 0-1.
Exclusion Criteria
- •Contraindications for TMS or MRI
- •History of epilepsy
- •Pregnancy
- •Other language disorder previous to the diagnosis of PPA
- •Neuroimaging not suggestive of PPA
Outcomes
Primary Outcomes
Changes in reading
Time Frame: 2 months
Story and words reading test
Changes in spontaneous speech (main primary endpoint)
Time Frame: 2 months (at baseline and at the end of the treatment)
Picture and story description task
Changes in oral naming
Time Frame: 2 months
Object naming test
Changes in repetition
Time Frame: 2 months (at baseline and at the end of the treatment)
Non-words and sentence repetition task
Secondary Outcomes
- Changes in brain metabolism(2 months (at baseline and at the end of the treatment))
- Changes in brain cortical electrical activity(2 months (at baseline and at the end of the treatment))
- Changes in clinical impression of change(2 months)
- Changes in global cognition(2 months (at baseline and at the end of the study))