Primary Progressive Aphasia Multicomponent Language Treatment Study

Not Applicable

• Conditions: Primary Progressive Aphasia; Semantic Dementia; Semantic Memory Disorder; Logopenic Progressive Aphasia; Nonfluent Aphasia, Progressive; Aphasia; Aphasia, Progressive

• Registration Number: NCT06649084
• Lead Sponsor: University of Texas at Austin

Brief Summary

The goal of this clinical trial is to learn if a speech-language telerehabilitation helps improve communication in people with primary progressive aphasia (PPA), a form of dementia that affects speech and language. The study will also document how acceptable and helpful the program is for both patients and their care partners.

The main questions the study aims to answer are:

1. Is the telerehabilitation program feasible and acceptable for people with PPA and their care partners?

2. Do participants with PPA and care partners report satisfaction with the program?

3. Which outcome measures are most useful for evaluating changes in communication and quality of life?

4. What patterns of treatment response are seen in participants after completing the program?

Researchers will test the program in a small group of participants to see how people respond. The program includes both speech-language therapy and training for care partners.

Participants will:

* Take part in online speech-language therapy sessions

* Complete communication tasks and questionnaires before and after the program

* Have regular virtual check-ins with the research team

* Include their care partners in some parts of the program for training and support

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-02
• Study First Submitted: 2024-10-16
• Study First Submitted QC: 2024-10-16
• Study First Posted: 2024-10-18
• Status Verified: 2025-09
• Last Update Submitted: 2025-10-05
• Last Update Posted: 2025-10-08
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
• Scores of 10 or higher on the Mini-Mental State Examination
• Has a study partner who can consistently attend sessions

Exclusion Criteria

• Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
• Significant, uncorrected visual or hearing impairment that would interfere with participation
• Score of less than 10 on the Mini-Mental State Examination
• Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in script production accuracy	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	Percent correct intelligible, scripted words for trained/untrained scripts
Change in spoken naming of trained/untrained items	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	Percent correctly named trained/untrained pictures
Information communicated in any modality for trained/untrained stimuli	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	Percent of major content units (key words) communicated via speech or nonspeech modalities (e.g., writing, drawing, gesture) for trained/untrained scripts (Multi-VISTA) or words (Multi-LRT) during structured probes and in conversation
Goal Attainment Score	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	The Goal Attainment Score is self-reported progress on personalized goals based on a five point scale.

Secondary Outcome Measures

Name	Time	Method
Change on Quick Aphasia Battery	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	change on standardized aphasia assessment
Change on Aphasia Impact Questionnaire	change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment	change on psychosocial questionnaire for individuals with aphasia

Trial Locations

Locations (1)

University of Texas; 🇺🇸 Austin, Texas, United States