Effect of ischemic postconditioning on targeting of Annexin A5 after forearm exercise

• Conditions: ischemic reperfusion injury; myocardial infarction; 10011082; 10003216

• Registration Number: NL-OMON30297
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

-Male
-Age 18-50 years
-No physical limitation to perform ischemic exercise
-Informed consent

Exclusion Criteria

-Diabetes (fasting glucose >7,0mmol/l, or random glucose >11,0mmol/l)
-hyperlipidemia (fasting total cholesterol > 5.5 mmol/l)
-Hypertension (supine SBP/DBP > 140/90 mmHg at screening)
-Any cardiovascular disease
-Drug abuse
-Concomittant chronic use of medication
-Administration of radioactivity in research setting during the last 5 years
-Participation to any drug-investigation during the previous month as checked with VIP check according to CRCN standard procedures.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Percentage difference in radioactivity (counts/pixel) between experimental and<br /><br>control thenar muscle at 60 and 240 minutes after reperfusion. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Workload during (ischemic) exercise. </p><br>