Optimization of SPECT Imaging

Not Applicable

Terminated

• Conditions: Coronary Artery Disease
• Interventions: Radiation: SPECT/CT processed with Evolution for CardiacTM software

• Registration Number: NCT01519973
• Lead Sponsor: Ottawa Heart Institute Research Corporation

Brief Summary

Single Photon Emission Computed Tomography (SPECT) is a 3D nuclear medicine imaging technique that is used extensively to study the heart and diagnose heart disease. There are three major limitations in SPECT imaging: attenuation or loss of signal, scattering of the signal in the patient tissues and resolution, where the signal gets blurrier the further the nuclear activity is away from the camera. New software, Evolution for CardiacTM, by GE Healthcare and new cameras with computed tomography (CT) decrease the time needed for images to be obtained while maintaining image quality. Evaluation is needed before they become standard of care.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-08
• Study First Submitted: 2011-07-15
• Study First Submitted QC: 2012-01-24
• Study First Posted: 2012-01-27
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-21
• Last Update Posted: 2017-04-24

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Intermediate to high risk patients with coronary artery disease who are scheduled for routine SPECT or PET perfusion imaging

Exclusion Criteria

• Pregnancy and breast feeding
• Severe narrowing (stenosis) of the aortic valve
• Severe heart failure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Evaluation of technology in SPECT	SPECT/CT processed with Evolution for CardiacTM software	Evaluation of the accuracy of SPECT with new technologies for attenuation correction (AC), scatter correction (SC) and resolution recovery (RR) for assessment of myocardial perfusion using Rb-82 PET as the gold standard.

Primary Outcome Measures

Name	Time	Method
• Determine the accuracy of myocardial perfusion assessment using SPECT with AC/SC/RR compared to Rb-82 PET.	2 years	We are proposing a study to evaluate the accuracy of SPECT with the new technologies for attenuation correction (AC), scatter compensation (SC) and resolution recovery (RR) for the assessment of myocardial perfusion in patients with heart disease using Rb-82 perfusion PET as the gold standard for comparison.

Secondary Outcome Measures

Name	Time	Method
Determine the incremental benefit of AC/SC/RR compared to AC alone	2 years
Determine if using a registered diagnostic CT (PET) increases the accuracy of CT-based AC over the lower-quality Hawkeye CT (SPECT).	2 years
Determine if using a single CT scan acquired at stress for attenuation correction of both stress and rest SPECT decreases the accuracy over using CT scans acquired separately at rest and stress.	2 years
Evaluate the effect on accuracy of using software with RR to reduce the acquisition time to half of the standard time.	2 years

Trial Locations

Locations (1)

University of Ottawa Heart Institute; 🇨🇦 Ottawa, Ontario, Canada