Effects of milk consumption on the urinary excretion of estrogens and progesterone: Relevance for the development of hormone-dependant tumors

Not Applicable

• Conditions: healthy postmenopausal study participants; in the broader sense effects of high milk consumption on the development of hormone-dependant tumors; C50; C61; Malignant neoplasm of breast; Malignant neoplasm of prostate

• Registration Number: DRKS00003377
• Lead Sponsor: Institut für Prävention und Tumorepidemiologie, Universitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2011-10-26
• Study Start: 2011-12-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 109

Inclusion Criteria

(1) postmenopausal women (last menstrual period at least 12 months ago) (2) non-smoking (3) good health / mobility

Exclusion Criteria

(1) HRT (at least 6 months ago) (2) intake of phytoestrogens (3) lactose intolerance (4) diseases: cancer, diabetes, bowel disease, liver / bile disease

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effect of milk consumption on urinary steroid hormone excretion (analysis of concentrations of estrogens, estrogen metabolites and pregnanediol-glucuronide): Individual differences (four-day milk intervention 1 - four-day depletion 1) of respective urinary steroid concentrations of main interest. Additional investigation of individual differences: four-day milk intervention 2 - four-day depletion 2 and four-day depletion 3 - four-day depletion 1.

Secondary Outcome Measures

Name	Time	Method
Effect of fat content of milk (1.5 % and 3.5 %) on urinary steroid hormone excretion (analysis of concentrations of estrogens, estrogen metabolites and pregnanediol-glucuronide): Analysis of variance for 2x2 crossover on the basis of individual differences (see Primary Outcome).