Markers for gut wall integrity : a novel diagnostic and prognostic tool in adult trauma patients?
Completed
- Conditions
- multi-trauma patientenaccidental injuriestrauma1001794310022114
- Registration Number
- NL-OMON35184
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 600
Inclusion Criteria
Trauma patients (every patient for which the UMCG trauma team will be summoned)
18 years of age or older
Exclusion Criteria
Age < 18
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>serum I-FABP, L-FABP and urine Claudin 3</p><br>
- Secondary Outcome Measures
Name Time Method <p>among others: age, sex, mechanism of injury, Revised Trauma Score (combining<br /><br>glascow coma scale, blood pressure and heart rate) upon admission, Abbreviated<br /><br>Injury Score/Injury Severity Score (anatomical scoring system for injury<br /><br>severity), EMTRA score (combining age, glascow coma scale, base excess, and<br /><br>prothrombin time) upon admission, SIRS score (combining temperature, heart<br /><br>rate, neutrophils count, respiratory rate, with a SIRS score >1 denoting the<br /><br>presence of SIRS), cytokine levels of TNFa, IL6, IL10</p><br>