The predictive value of PET-CT and PET-DW-MRI early during chemoradiotherapy for head and neck cancer
Recruiting
- Registration Number
- NL-OMON28050
- Lead Sponsor
- Prof. dr. R. de BreeDepartment of Otolaryngology/ Head and Neck surgeryVU University Medical Center1081 HV Amsterdam+31204443689+31204443688r.bree@vumc.nl
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Squamous cell carcinoma
-Oral cavity, pharynx or larynx
Exclusion Criteria
-Age < 18 years
-Pregnancy
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate the diagnostic value of FDG-PET-CT and DW-MRI (EPI and non-EPI technique) applied 2 weeks after the start of primary chemoradiotherapy for HNSCC to predict locoregional response in the primary tumor and cervical node metastases.
- Secondary Outcome Measures
Name Time Method To determine the value of different criteria, related to the primary objective, such as:<br /><br>•FDG uptake level pretreatment (on PET-CT and PET-MRI)<br /><br>•Residual FDG uptake level after 14 days of therapy (on PET-CT and PET-MRI)<br /><br>•Change of FDG uptake (on PET-CT and PET-MRI)<br /><br>•b=1000 signal intensity and ADC level pretreatment (for both EPI- and non-EPI-technique)<br /><br>•Residual b=1000 signal intensity and ADC level after 14 days of therapy (for both EPI- and non-EPI-technique)<br /><br>•Change of b=1000 signal intensity and ADC (for both EPI- and non-EPI-technique)<br>FDG-uptake levels obtained from PET-CT and PET-MRI will be compared (taking into account the different time intervals between FDG-injection and scanning)