KCT0009435招募中Unknown
Comparison of the effect of intravenous ondansetron administration on vasopressor requirements and the corrected QT for preventing spinal hypotension during cesarean delivery under spinal anesthesia: A Prospective, Randomized, double-blinded study
适应症
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 入组人数
- 110
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20(Year) 至 45(Year)（—）
- 性别
- Female
入选标准
- •1) Singleton, Gestational age 37 weeks or more
- •2) Scheduled for spinal anesthesia
- •3) from 20 years to 45 years
- •4) No contraindications of spinal anesthesia
- •5) Body mass index 35 kg/m2 or less
- •6) American society of anesthesiologists physical status 2
排除标准
- •1) Past history of side effects related to the use of ondansetron, history of inadequate response to the antiemetic effect of ondansetron
- •2) Failure of spinal anesthesia (conversion to general anesthesia, unexpected analgesia or sedatives administration due to inadequate spinal anesthesia)
- •3) Emergency cesarean section (category 1) such as placental abruption, umbilical cord prolapse
- •4) Cases where blood transfusion is expected (etc. placenta accreta spectrum)
- •5) Accompanying pregnancy related complications such as hypertension, pre-eclampsia, eclampsia , etc
- •6) Magnesium treatment during the pre/postoperative period
- •7) Electrolyte imbalance including hypokalemia, hypomagnesemia and others, Drug administration causing electrolyte imbalance
- •8) Congestive heart failure, possibility or presence of Long QT syndrome, and brady-arrhythmia
- •9) Administration of Selective-serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor
- •10) Drug administration related to QT prolongation: Cardiotoxic drugs (e.g.anthracycline), antibiotics (e.g.erythromycin), anti-fungal agents (e.g.ketoconazol), anti-arrhythmic agents (e.g.amiodarone), beta-blocker, etc
- •11) If there is or is expected to be a neurological deficit
- •12) Expected birth weight less than 1500 (Very low birth weight)
- •13) Patient who have already administered a Selective 5-HT3 receptor antagonist, or patients having an allergy or hypersensitivity to selective 5-HT3 receptor antagonist
- •14) Regarded as inappropriate to participate this study by Medical staff
研究者
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