Role of Oral Activated Charcoal in Decreasing Blood Urea, Creatinine and Phosphorous in Chronic Kidney Disease
试验速览
- 阶段
- 2 期
- 入组人数
- 90
- 主要终点
- Mean of blood urea, creatinine and phosphorous in patients with CKD before and after oral activated charcoal
研究概览
简要总结
The study aims to explore the ability of Oral activated charcoal to adsorb uremic toxins limiting the progression of chronic kidney disease and delaying the need for hemodialysis in patients with CKD stages III and IV.
To compare its effect with the effect of dry seeds as absorbents of uremic toxins
详细描述
In recent years, chronic kidney disease(CKD) has become a worldwide public health issue.
The main factors affecting the prognosis of patients with chronic kidney disease are its complications, including cardiovascular and cerebrovascular diseases, malnutrition, inflammation, atherosclerosis syndrome, and anemia.
The accumulation of uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, is implicated in the progression of renal failure and cardiovascular disease.
For many patients, chronic kidney disease (CKD) is a progressive condition marked by deteriorating renal function ultimately leading to end-stage renal disease (ESRD) and many patients refuse to start chronic hemodialysis.
Therapeutic approaches that decrease the level of uremic toxins are a rational method for inhibiting this progression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with CKD stages iii and iv
- •Patients with age more than 18 years old
排除标准
- •Patients on regular hemodialysis
- •Patients with age less than 18 years old
研究组 & 干预措施
1st group
Oral activated charcoal in a dose of 30 gm/day
干预措施: Activated charcoal (Drug)
2nd group
Dry seeds in a dose of 1 gm/ day
干预措施: Dry seeds (Dietary Supplement)
结局指标
主要结局
Mean of blood urea, creatinine and phosphorous in patients with CKD before and after oral activated charcoal
时间窗: baseline
to asses the mean of blood urea, creatinine and phosphorous in CKD patient before and after administration of activated charcoal
次要结局
- comparison of dry seeds and activated charcoal in limitting progression of chronic kidney disease(baseline)
研究者
Farrag Sayed Mohamed
Resident Doctor, internal medicine department, principal investigator
Assiut University