Role of Activated Charcoal in Decreasing Blood Urea, Creatinine and Phosphorous
- Conditions
- Chronic Kidney Disease stage3
- Interventions
- Drug: Activated charcoalDietary Supplement: Dry seeds
- Registration Number
- NCT04311645
- Lead Sponsor
- Assiut University
- Brief Summary
The study aims to explore the ability of Oral activated charcoal to adsorb uremic toxins limiting the progression of chronic kidney disease and delaying the need for hemodialysis in patients with CKD stages III and IV.
To compare its effect with the effect of dry seeds as absorbents of uremic toxins
- Detailed Description
In recent years, chronic kidney disease(CKD) has become a worldwide public health issue.
The main factors affecting the prognosis of patients with chronic kidney disease are its complications, including cardiovascular and cerebrovascular diseases, malnutrition, inflammation, atherosclerosis syndrome, and anemia.
The accumulation of uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, is implicated in the progression of renal failure and cardiovascular disease.
For many patients, chronic kidney disease (CKD) is a progressive condition marked by deteriorating renal function ultimately leading to end-stage renal disease (ESRD) and many patients refuse to start chronic hemodialysis.
Therapeutic approaches that decrease the level of uremic toxins are a rational method for inhibiting this progression.
Many researches have been done aiming to find alternatives for chronic hemodialysis either for economic issues or psychological issues especially in elderly patients, as example:
* Gum Arabic in the remedy and amelioration of kidney dysfunction and end-stage renal disease
* skin as excretory root for urea, increasing sweat from sweat glands can support kidney function by excreting a good amount of what kidneys naturally excrete.
* The oral charcoal adsorbent reduces serum levels of indoxyl sulfate through adsorption of indole converted from dietary tryptophan in the gastrointestinal tract decreasing serum creatinine and urea level .
In this study, the clinical data supporting the role of oral activated charcoal in a dose of 30gm/ day for slowing the progression of CKD will be reviewed.
In this study, a trial will be done using dry seeds (lentils as an example) as an absorbent for uremic toxins comparing its effect with the effect of oral activated charcoal.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 90
Patients with CKD stages iii and iv
Patients with age more than 18 years old
Patients on regular hemodialysis
Patients with age less than 18 years old
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1st group Activated charcoal Oral activated charcoal in a dose of 30 gm/day 2nd group Dry seeds Dry seeds in a dose of 1 gm/ day
- Primary Outcome Measures
Name Time Method Mean of blood urea, creatinine and phosphorous in patients with CKD before and after oral activated charcoal baseline to asses the mean of blood urea, creatinine and phosphorous in CKD patient before and after administration of activated charcoal
- Secondary Outcome Measures
Name Time Method comparison of dry seeds and activated charcoal in limitting progression of chronic kidney disease baseline To compare dry seeds with activated charcoal as as alternative natural cheap methods that may help in limitting progression of CKD by measuring blood urea, creatinine, and phosphorous in all 3 groups of the study