VItamin C in Thermal injuRY: The VICToRY Trial A phase III multi-center randomized trial - 19-211

Queen's University At Kingston0 个研究点目标入组 373 人开始时间: 2023年4月5日最近更新: 2024年8月21日

适应症

试验速览

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•18 years of age or older with deep 2nd and/or 3rd degree burns, who are assessed as requiring skin grafting, and a minimum burn size = 20% Total Body Surface Area (TBSA). Patients with smaller burns are less likely to require fluid resuscitation and their risk of morbidity and mortality is lower. Burn size will be determined by the attending physician (and confirmed by the attending surgeon if it is not the same person).

•>24 hrs from admission to participating hospital to consent., Patients admitted to burn unit >24 from injury or accident., Patients who are moribund (not expected to survive the next 72 hours)., Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating., Enrolment in another industry sponsored intensive care unit (ICU) intervention study., Receiving high-dose intravenous (IV) vitamin C already (enteral or oral vitamin C is allowed)., Known glucose-6-phosphate dehydrogenase (G6PD) deficiency., Recent history of kidney stones (within the last year)., Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.

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