Dynamicity of Echocardiography During Ajmaline Test
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Speckle tracking strain measurement
研究概览
简要总结
In this study the investigators analyse echocardiographic images before and during Ajmaline test. The purpose is to know if any echocardiographic modifications are present during either negative or positive Ajmaline testing.
详细描述
The diagnosis of Brugada Syndrome is made when a type 1 pattern is present on the electrocardiogram (ECG), either spontaneously or after administration of a sodium channel blocker. For pathofysiological understanding, the investigators will analyse echocardiography images before and during the administration of Ajmaline. Comparing echocardiographies before and during negative Ajmaline test, will allow the investigators to indentify the effect of Ajmaline administration on cardiac function. The comparison between images of negative and positive Ajmaline tests will expose differences related to the occurence of a type 1 ECG.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>17 years old
- •clinical indication for Ajmaline test
排除标准
- •History of right ventricular outflow tract ablation
研究组 & 干预措施
Negative Ajmaline test
No appearance of a type 1 ECG during Ajmaline test
干预措施: Ajmaline test (Drug)
Positive Ajmaline test
Appearance of a type 1 ECG during Ajmaline test
干预措施: Ajmaline test (Drug)
结局指标
主要结局
Speckle tracking strain measurement
时间窗: 1 day at the time of enrollment
Cardiac function assessed by speckle tracking peak strain and peak strain dispersion
次要结局
未报告次要终点
研究者
Esther Scheirlynck
Principal Investigator
Universitair Ziekenhuis Brussel