Open-label Extension Study of Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension
- Registration Number
- NCT06492291
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Brief Summary
This is an extension study to evaluate the longer-term safety and efficacy of enlicitide decanoate in adults with hypercholesterolemia who completed either study MK-0616-013 (NCT05952856), study MK-0616-017 (NCT05952869), or study MK-0616-018 (NCT06450366).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 3000
- Has completed an enlicitide decanoate parent study [MK-0616-013 (NCT05952856), MK-0616-017 (NCT05952869), and MK-0616-018 (NCT Number pending)] per protocol (including the final assessments/procedures of their parent study)
- Had an overall study intervention compliance ≥80% while participating in their parent study
- Has discontinued study intervention in their parent study
- Has an ongoing serious adverse event considered related to study intervention by the investigator in the parent study
- Is currently participating in an interventional clinical study other than an enlicitide decanoate parent study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Enlicitide Decanoate Enlicitide Decanoate Participants will receive 20 mg of enlicitide decanoate orally once daily (QD)
- Primary Outcome Measures
Name Time Method Number of participants with one or more adverse events (AEs) Up to approximately 3 years An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
Number of participants who discontinue study drug due to an AE Up to approximately 3 years An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention.
- Secondary Outcome Measures
Name Time Method Mean percent change from baseline of the parent study in non-high-density lipoprotein cholesterol (non-HDL-C) at Week 8 of this Extension Study Baseline of the parent study and Week 8 of this extension study The percent change from baseline in Non-HDL-C. Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Percent change from baseline of the parent study in lipoprotein(a) (Lp[a]) at Week 8 of this extension study Baseline of the parent study and Week 8 of this extension study The percent change from baseline in Lp(a). Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Mean percent change from baseline of the parent study in LDL-C at Week 8 of this extension study Baseline of the parent study and Week 8 of this extension study The percent change from baseline in LDL-C. Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Mean percent change from baseline of the parent study in apolipoprotein B (ApoB) at Week 8 of this extension study Baseline of the parent study and Week 8 of this extension study The percent change from baseline in apolipoprotein B. Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Percentage of participants with LDL-C <70 mg/dL and ≥50% reduction from baseline of the parent study Baseline in the parent study and up to approximately 3 years in this extension study The percentage of participants who have LDL-C \<70 mg/dL and ≥50% reduction from baseline at any point during the study. Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Percentage of participants with LDL-C <55 mg/dL and ≥50% reduction from baseline of the parent study Baseline in the parent study and up to approximately 3 years in this extension study The percentage of participants who have LDL-C \<55 mg/dL and ≥50% reduction from baseline at any point during the study. Each participant's baseline data from their parent study will be used as baseline data for this analysis.
Trial Locations
- Locations (222)
Rambam Health Care Campus ( Site 1742)
🇮🇱Haifa, Israel
Alliance for Multispecialty Research, LLC ( Site 0027)
🇺🇸Daphne, Alabama, United States
G&L Research ( Site 0035)
🇺🇸Foley, Alabama, United States
Synexus Clinical Research US, Inc.-Synexus Clinical Research US, Inc - Central Phoenix ( Site 0048)
🇺🇸Phoenix, Arizona, United States
Chengdu Second Municipal People's Hospital ( Site 6032)
🇨🇳Chengdu, Sichuan, China
National Heart Institute-Research ( Site 0029)
🇺🇸Beverly Hills, California, United States
Clinical Trials Research ( Site 0054)
🇺🇸Sacramento, California, United States
Velocity Clinical Research, Banning ( Site 0023)
🇺🇸San Bernardino, California, United States
Emerson Clinical Research Institute ( Site 0017)
🇺🇸Washington, District of Columbia, United States
Excel Medical Clinical Trials ( Site 0010)
🇺🇸Boca Raton, Florida, United States
Alliance for Multispecialty Research, LLC ( Site 0037)
🇺🇸Coral Gables, Florida, United States
Alliance for Multispecialty Research, LLC ( Site 0056)
🇺🇸Fort Myers, Florida, United States
Shaare Zedek Medical Center ( Site 1735)
🇮🇱Jerusalem, Israel
Velocity Clinical Research, Hallandale Beach ( Site 0053)
🇺🇸Hallandale Beach, Florida, United States
Jacksonville Center for Clinical Research ( Site 0025)
🇺🇸Jacksonville, Florida, United States
South Broward Research ( Site 0012)
🇺🇸Miramar, Florida, United States
Progressive Medical Research ( Site 0033)
🇺🇸Port Orange, Florida, United States
Clinical Research Trials of Florida ( Site 0006)
🇺🇸Tampa, Florida, United States
Clinical Site Partners, LLC dba Flourish Research ( Site 0004)
🇺🇸Winter Park, Florida, United States
East Coast Institute for Research, LLC ( Site 0020)
🇺🇸Macon, Georgia, United States
Healthcare Research Network - Chicago ( Site 0051)
🇺🇸Flossmoor, Illinois, United States
Synexus Clinical Research US - Evansville ( Site 0005)
🇺🇸Evansville, Indiana, United States
Midwest Institute For Clinical Research ( Site 0052)
🇺🇸Indianapolis, Indiana, United States
Alliance for Multispecialty Research, LLC ( Site 0001)
🇺🇸Lexington, Kentucky, United States
L-MARC Research Center ( Site 0011)
🇺🇸Louisville, Kentucky, United States
Velocity Clinical Research, Covington ( Site 0026)
🇺🇸Covington, Louisiana, United States
Velocity Clinical Research Rockville ( Site 0022)
🇺🇸Rockville, Maryland, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division ( Site 0018)
🇺🇸Troy, Michigan, United States
Velocity Clinical Research, Gulfport ( Site 0032)
🇺🇸Gulfport, Mississippi, United States
Healthcare Research Network - St. Louis ( Site 0040)
🇺🇸Hazelwood, Missouri, United States
Velocity Clinical Research at The Pioneer Heart Institute, Lincoln ( Site 0031)
🇺🇸Lincoln, Nebraska, United States
Jubilee Clinical Research ( Site 0049)
🇺🇸Las Vegas, Nevada, United States
AB Clinical Trials ( Site 0002)
🇺🇸Las Vegas, Nevada, United States
Hadassah Medical Center ( Site 1732)
🇮🇱Jerusalem, Israel
New Mexico Clinical Research & Osteoporosis Center ( Site 0043)
🇺🇸Albuquerque, New Mexico, United States
Velocity Clinical Research, Syracuse ( Site 0014)
🇺🇸East Syracuse, New York, United States
Icahn School of Medicine at Mount Sinai-Cardiology ( Site 0042)
🇺🇸New York, New York, United States
Lillestol Research ( Site 0030)
🇺🇸Fargo, North Dakota, United States
altoona center for clinical research ( Site 0024)
🇺🇸Duncansville, Pennsylvania, United States
Cardiology Consultants of Philadelphia Yardley ( Site 0021)
🇺🇸Yardley, Pennsylvania, United States
Velocity Clinical Research, Anderson ( Site 0015)
🇺🇸Anderson, South Carolina, United States
Piedmont Research Partners ( Site 0045)
🇺🇸Fort Mill, South Carolina, United States
Coastal Carolina Research Center ( Site 0055)
🇺🇸North Charleston, South Carolina, United States
Monument Health Clinical Research, a department of Monument -Monument Health Clinical Research, a d
🇺🇸Rapid City, South Dakota, United States
Holston Medical Group ( Site 0034)
🇺🇸Kingsport, Tennessee, United States
Alliance for Multispecialty Research, LLC ( Site 0050)
🇺🇸Knoxville, Tennessee, United States
Velocity Clinical Research, Dallas ( Site 0028)
🇺🇸Dallas, Texas, United States
Center for Cardiometabolic Disease Prevention/Baylor College of Medicine ( Site 0009)
🇺🇸Houston, Texas, United States
Clinical Trials of Texas, LLC ( Site 0016)
🇺🇸San Antonio, Texas, United States
Synexus Clinical Research US, Inc. ( Site 0003)
🇺🇸Salt Lake City, Utah, United States
Velocity Clinical Research, Salt Lake City ( Site 0041)
🇺🇸West Jordan, Utah, United States
Manassas Clinical Research Center ( Site 0007)
🇺🇸Manassas, Virginia, United States
Health Research of Hampton Roads, Inc. ( Site 0019)
🇺🇸Newport News, Virginia, United States
Alliance for Multispecialty Research, LLC ( Site 0008)
🇺🇸Norfolk, Virginia, United States
National Clinical Research, Inc ( Site 0044)
🇺🇸Richmond, Virginia, United States
Rainier Clinical Research Center ( Site 0013)
🇺🇸Renton, Washington, United States
CEDIC ( Site 0603)
🇦🇷Caba, Buenos Aires, Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0605)
🇦🇷Caba, Buenos Aires, Argentina
Fundación Respirar ( Site 0606)
🇦🇷Caba, Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0602)
🇦🇷Mar del Plata, Buenos Aires, Argentina
Instituto de Investigaciones Clinicas Zarate ( Site 0604)
🇦🇷Zárate, Buenos Aires, Argentina
Fundacion Estudios Clinicos ( Site 0601)
🇦🇷Rosario, Santa Fe, Argentina
Centro de Investigaciones Metabolicas CINME - Cardiology ( Site 0607)
🇦🇷Caba, Argentina
CIPREC ( Site 0600)
🇦🇷Caba, Argentina
Royal Prince Alfred Hospital-6West CV Ambulatory Care ( Site 2808)
🇦🇺Camperdown, New South Wales, Australia
Victorian Heart Hospital-Monash Cardiovascular Research Centre (MCRC) ( Site 2803)
🇦🇺Clayton, Victoria, Australia
Universidade Federal Do Ceara ( Site 0702)
🇧🇷Fortaleza, Ceara, Brazil
Instituto Dante Pazzanese de Cardiology ( Site 0701)
🇧🇷São Paulo, Sao Paulo, Brazil
Incor - Instituto do Coracao ( Site 0703)
🇧🇷Sao Paulo, Brazil
The Medical Arts Health Research Group ( Site 0506)
🇨🇦North Vancouver, British Columbia, Canada
Cambridge Cardiac Care Centre ( Site 0502)
🇨🇦Cambridge, Ontario, Canada
North York Diagnostic and Cardiac Centre ( Site 0505)
🇨🇦North York, Ontario, Canada
Ecogene-21 ( Site 0500)
🇨🇦Chicoutimi, Quebec, Canada
Institut de Cardiologie de Montreal ( Site 0504)
🇨🇦Montreal, Quebec, Canada
Diex Recherche Trois-Rivieres ( Site 0503)
🇨🇦Trois-Rivieres, Quebec, Canada
Clinical Research Chile SpA ( Site 0800)
🇨🇱Valdivia, Los Rios, Chile
CDIEM ( Site 0801)
🇨🇱Providencia, Region M. De Santiago, Chile
Pontificia Universidad Catolica de Chile-CICUC ( Site 0803)
🇨🇱Santiago, Region M. De Santiago, Chile
Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 6000)
🇨🇳Beijing, Beijing, China
Beijing Friendship Hospital Affiliate of Capital University ( Site 6003)
🇨🇳Beijing, Beijing, China
The Second Affiliated Hospital of Chongqing Medical University ( Site 6020)
🇨🇳Chongqing, Chongqing, China
Chongqing University Three Gorges Hospital ( Site 6021)
🇨🇳Chongqing, Chongqing, China
Guangdong Provincial People s Hospital ( Site 6004)
🇨🇳Guangzhou, Guangdong, China
Zhujiang Hospital ( Site 6029)
🇨🇳Guangzhou, Guangdong, China
Huizhou Municipal Central Hospital ( Site 6079)
🇨🇳Huizhou, Guangdong, China
The University of Hong Kong-Shenzhen Hospital ( Site 6018)
🇨🇳Shenzhen, Guangdong, China
Jingzhou Central Hospital ( Site 6076)
🇨🇳Jingzhou, Hubei, China
Wuhan Fourth Hospital ( Site 6056)
🇨🇳Wuhan, Hubei, China
Hunan Provincial People's Hospital ( Site 6017)
🇨🇳Changsha, Hunan, China
Changzhou Second People's Hospital ( Site 6073)
🇨🇳Changzhou, Jiangsu, China
Northern Jiangsu People s Hospital ( Site 6008)
🇨🇳Yangzhou, Jiangsu, China
The Third Hospital of Nanchang - Fuhe ( Site 6078)
🇨🇳Nanchang, Jiangxi, China
Siping Central People's Hospital ( Site 6011)
🇨🇳Siping, Jilin, China
Xianyang Hospital of Yan'an University ( Site 6040)
🇨🇳Xianyang City, Shaanxi, China
Lishui City People s Hospital ( Site 6002)
🇨🇳Lishui, Zhejiang, China
Fundación Centro de Investigación Clínica CIC ( Site 0904)
🇨🇴Medellín, Antioquia, Colombia
Ciensalud Ips S A S ( Site 0900)
🇨🇴Barranquilla, Atlantico, Colombia
Clinica de la Costa S.A.S. ( Site 0901)
🇨🇴Barranquilla, Atlantico, Colombia
Salud SURA Calle 100 ( Site 0905)
🇨🇴Bogotá, Cundinamarca, Colombia
Healthy Medical Center S.A.S ( Site 0902)
🇨🇴Zipaquira, Cundinamarca, Colombia
Fundación Valle del Lili ( Site 0903)
🇨🇴Cali, Valle Del Cauca, Colombia
Fakultni Nemocnice u sv. Anny v Brne ( Site 3604)
🇨🇿Brno, Brno-mesto, Czechia
Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 3602)
🇨🇿Brno, Brno-mesto, Czechia
Institut Klinicke a Experimentalni Mediciny ( Site 3601)
🇨🇿Prague, Praha 4, Czechia
Meilahden tornisairaala - Meilahti Tower Hospital ( Site 1300)
🇫🇮Helsinki, Uusimaa, Finland
Hôpital Arnaud de Villeneuve - CHU Montpellier ( Site 5002)
🇫🇷Montpellier, Herault, France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes ( Site 5004)
🇫🇷Saint-Herblain, Loire-Atlantique, France
Hospices Civils de Lyon - Hopital Louis Pradel-Service d'endocrinologie, de diabétologie et des mal
🇫🇷Bron, Rhone, France
Unterfrintroper Hausarztzentrum Klinische Forschung ( Site 1543)
🇩🇪Essen, Nordrhein-Westfalen, Germany
Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels ( Site 1528)
🇩🇪Hohenmoelsen, Sachsen-Anhalt, Germany
Universitaetsklinikum Carl Gustav Carus Dresden-Universitätsstudienzentrum für Stoffwechselerkranku
🇩🇪Dresden, Sachsen, Germany
Zentralklinik Bad Berka ( Site 1531)
🇩🇪Bad Berka, Thuringen, Germany
Velocity Clinical Research GmbH Berlin ( Site 1503)
🇩🇪Berlin, Germany
Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 1534)
🇩🇪Berlin, Germany
Queen Mary Hospital-Medical ( Site 3300)
🇭🇰Hksar, Hong Kong
Prince of Wales Hospital ( Site 3304)
🇭🇰Shatin, Hong Kong
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1603)
🇭🇺Szeged, Csongrad, Hungary
Semmelweis Egyetem-Városmajori Szív- és Érgyógyászati Klinika ( Site 1600)
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Anyagcsere Tanszék) ( Site 1601)
🇭🇺Debrecen, Hungary
Hillel Yaffe Medical Center ( Site 1731)
🇮🇱Hadera, Israel
Rambam Health Care Campus ( Site 1739)
🇮🇱Haifa, Israel
Hadassah Medical Center ( Site 1741)
🇮🇱Jerusalem, Israel
Hadassah Medical Center-Heart Institute ( Site 1734)
🇮🇱Jerusalem, Israel
Meir Medical Center. ( Site 1737)
🇮🇱Kfar Saba, Israel
Rabin Medical Center ( Site 1738)
🇮🇱Petah Tikva, Israel
Rabin Medical Center ( Site 1740)
🇮🇱Petah Tikva, Israel
Sheba Medical Center ( Site 1733)
🇮🇱Ramat Gan, Israel
Clalit Health Services - Sakhnin Community Clinic ( Site 1730)
🇮🇱Sakhnin, Israel
Yitzhak Shamir Medical Center. ( Site 1736)
🇮🇱Zerifin, Israel
Fondazione Policlinico Tor Vergata ( Site 1809)
🇮🇹Rome, Lazio, Italy
Centro Cardiologico Monzino ( Site 1804)
🇮🇹Milan, Milano, Italy
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1801)
🇮🇹Torino, Piemonte, Italy
Azienda Ospedaliera Sant'Andrea-Department of Clinical and Molecular Medicine ( Site 1807)
🇮🇹Rome, Roma, Italy
Azienda Ospedaliera Garibaldi ( Site 1810)
🇮🇹Catania, Italy
Hirohata Naika Clinic ( Site 3513)
🇯🇵Kitakyushu, Fukuoka, Japan
Nakakinen clinic ( Site 3510)
🇯🇵Naka, Ibaraki, Japan
Noritake Clinic ( Site 3512)
🇯🇵Ushiku, Ibaraki, Japan
National Hospital Organization Kanazawa Medical Center ( Site 3508)
🇯🇵Kanazawa, Ishikawa, Japan
Hirano Medical Clinic ( Site 3522)
🇯🇵Morioka, Iwate, Japan
Shirai Healthcare Clinic Izumichuou ( Site 3527)
🇯🇵Sendai, Miyagi, Japan
Rinku General Medical Center ( Site 3503)
🇯🇵Izumisano, Osaka, Japan
Shiraiwa Medical Clinic ( Site 3514)
🇯🇵Kashiwara, Osaka, Japan
Medical Corporation Heishinkai OCROM Clinic ( Site 3501)
🇯🇵Suita-shi, Osaka, Japan
Saitama Medical University Hospital ( Site 3506)
🇯🇵Iruma, Saitama, Japan
Teramoto Medical and Dental Clinic ( Site 3507)
🇯🇵Bunkyo-ku, Tokyo, Japan
Tokyo-Eki Center-building Clinic ( Site 3505)
🇯🇵Chuo-ku, Tokyo, Japan
Fukuwa Clinic ( Site 3504)
🇯🇵Chuo-ku, Tokyo, Japan
Teikyo University Hospital ( Site 3500)
🇯🇵Itabashi-ku, Tokyo, Japan
Kato Clinic of Internal Medicine ( Site 3509)
🇯🇵Katsushika-ku, Tokyo, Japan
Kanno Naika ( Site 3511)
🇯🇵Mitaka, Tokyo, Japan
Sugawara Clinic ( Site 3519)
🇯🇵Nerima-ku, Tokyo, Japan
Shin Clinic ( Site 3517)
🇯🇵Ota-ku, Tokyo, Japan
Medical Corporation Heishinkai ToCROM Clinic ( Site 3502)
🇯🇵Shinjuku-ku, Tokyo, Japan
Medical Corporation Hakuaikai Wellness Tenjin Clinic ( Site 3520)
🇯🇵Fukuoka, Japan
Hiroshima City Hiroshima Citizens Hospital ( Site 3518)
🇯🇵Hiroshima, Japan
Mishuku Hospital ( Site 3524)
🇯🇵Tokyo, Japan
Mitsukoshi Health and Welfare Foundation ( Site 3521)
🇯🇵Tokyo, Japan
Chungbuk National University Hospital ( Site 3011)
🇰🇷Cheongju-si, Chungbuk, Korea, Republic of
Wonju Severance Christian Hospital ( Site 3008)
🇰🇷Wonju, Kang-won-do, Korea, Republic of
Chonnam National University Hospital ( Site 3014)
🇰🇷Gwangju-si, Kwangju-Kwangyokshi, Korea, Republic of
Seoul National University Bundang Hospital ( Site 3005)
🇰🇷Seongnam, Kyonggi-do, Korea, Republic of
Ajou University Hospital ( Site 3006)
🇰🇷Suwon, Kyonggi-do, Korea, Republic of
Dong-A University Hospital-Cardiology ( Site 3013)
🇰🇷Busan, Pusan-Kwangyokshi, Korea, Republic of
Pusan National University Hospital-Internal Medicine ( Site 3012)
🇰🇷Busan, Pusan-Kwangyokshi, Korea, Republic of
Inje University Haeundae Paik Hospital ( Site 3010)
🇰🇷Haeundae-gu, Pusan-Kwangyokshi, Korea, Republic of
Keimyung University Dongsan Hospital CRC room 1 ( Site 3003)
🇰🇷Daegu, Taegu-Kwangyokshi, Korea, Republic of
Seoul National University Hospital ( Site 3001)
🇰🇷Seoul, Korea, Republic of
Kangbuk Samsung Hospital ( Site 3009)
🇰🇷Seoul, Korea, Republic of
Severance Hospital, Yonsei University Health System ( Site 3002)
🇰🇷Seoul, Korea, Republic of
Asan Medical Center ( Site 3004)
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center-cardiology ( Site 3000)
🇰🇷Seoul, Korea, Republic of
The Catholic Univ. of Korea Seoul St. Mary's Hospital-cardiology ( Site 3007)
🇰🇷Seoul, Korea, Republic of
Instituto Nacional de Ciencias Medicas y Nutricion Salvador -Unidad de Investigación de Enfermedade
🇲🇽Mexico City, Distrito Federal, Mexico
Instituto Jalisciense de Investigacion en Diabetes y Obesidad-Endocrinology ( Site 1057)
🇲🇽Guadalajara, Jalisco, Mexico
Radboudumc-internal medicine ( Site 1952)
🇳🇱Nijmegen, Gelderland, Netherlands
Amsterdam UMC, locatie AMC-Vascular Medicine Clin Trial Unit ( Site 1954)
🇳🇱Amsterdam, Noord-Holland, Netherlands
Dijklander Ziekenhuis ( Site 1953)
🇳🇱Hoorn, Noord-Holland, Netherlands
Universitair Medisch Centrum Utrecht-Vascular Medicine Research ( Site 1955)
🇳🇱Utrecht, Netherlands
Pacific Clinical Research Network - Rotorua ( Site 2902)
🇳🇿Rotorua, Bay Of Plenty, New Zealand
New Zealand Clinical Research (Christchurch) ( Site 2901)
🇳🇿Christchurch, Canterbury, New Zealand
Nordlandssykehuset ( Site 2041)
🇳🇴Bodø, Nordland, Norway
Oslo Universitetssykehus Aker-Lipidklinikken ( Site 2040)
🇳🇴Oslo, Norway
Changi General Hospital ( Site 3211)
🇸🇬Singapore, Central Singapore, Singapore
IATROS International ( Site 2204)
🇿🇦Bloemfontein, Free State, South Africa
Charlotte Maxeke Johannesburg Academic Hospital ( Site 2202)
🇿🇦Johannesburg, Gauteng, South Africa
Soweto Clinical Trials Centre ( Site 2203)
🇿🇦Soweto, Gauteng, South Africa
TREAD Research ( Site 2201)
🇿🇦Cape Town, Western Cape, South Africa
Tiervlei Trial Centre ( Site 2205)
🇿🇦Cape Town, Western Cape, South Africa
University of Cape Town (UCT)-Medicine, Division of Lipidology ( Site 2200)
🇿🇦Cape Town, Western Cape, South Africa
Hospital Universitario Virgen de la Victoria-UGC Endocrinologia y nutricion ( Site 2358)
🇪🇸Malaga, Andalucia, Spain
EBA CENTELLES ( Site 2319)
🇪🇸Centelles, Barcelona, Spain
Hospital Universitari Vall d'Hebron ( Site 2362)
🇪🇸Barcelona, Cataluna, Spain
Hospital de Figueres ( Site 2361)
🇪🇸Figueres, Gerona, Spain
Hospital Abente y Lago ( Site 2356)
🇪🇸A Coruña, La Coruna, Spain
Hospital San Rafael de Coruna ( Site 2363)
🇪🇸A Coruña, La Coruna, Spain
CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 2320)
🇪🇸Santiago de compostela, La Coruna, Spain
Hospital Universitario Fundacion ALcorcon-Endocrinologia y Nutrición ( Site 2316)
🇪🇸Alcorcón, Madrid, Comunidad De, Spain
HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 2344)
🇪🇸Pozuelo de Alarcon, Madrid, Spain
Vithas Hospital Sevilla-Unidad de Salud Metabólica. Diabetes y Obesidad ( Site 2349)
🇪🇸Castilleja de la Cuesta, Sevilla, Spain
Hospital Universitari Sant Joan de Reus ( Site 2329)
🇪🇸Reus, Tarragona, Spain
HOSPITAL CLINICO DE VALENCIA-CARDIOLOGY ( Site 2321)
🇪🇸Valencia, Valenciana, Comunitat, Spain
EAP Sardenya ( Site 2357)
🇪🇸Barcelona, Spain
Hospital Universitario 12 de Octubre-Internal Medicine. Unidad de Ensayos Clínicos ( Site 2311)
🇪🇸Madrid, Spain
Hospital Universitario Virgen Macarena-Cardiology ( Site 2352)
🇪🇸Sevilla, Spain
Changhua Christian Hospital ( Site 3101)
🇨🇳Changhua County, Changhua, Taiwan
Chang Gung Memorial Hospital at Kaohsiung ( Site 3102)
🇨🇳Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Mackay Memorial Hospital -Tamsui Branch ( Site 3109)
🇨🇳New Taipei City, New Taipei, Taiwan
Chi Mei Medical Center ( Site 3104)
🇨🇳Tainan City, Tainan, Taiwan
Shin Kong Wu Ho-Su Memorial Hospital ( Site 3110)
🇨🇳Taipei City, Taipei, Taiwan
National Cheng Kung University Hospital-Internal Medicine ( Site 3107)
🇨🇳Tainan, Taiwan
National Taiwan University Hospital ( Site 3100)
🇨🇳Taipei, Taiwan
Taipei Medical University Hospital ( Site 3108)
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital ( Site 3106)
🇨🇳Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch ( Site 3105)
🇨🇳Taoyuan, Taiwan
Ege Universitesi Hastanesi-Cardilogy Department ( Site 2502)
🇹🇷Bornova, Izmir, Turkey
Hacettepe Universite Hastaneleri ( Site 2500)
🇹🇷Ankara, Turkey
Ankara Bilkent Şehir Hastanesi-cardiology ( Site 2501)
🇹🇷Ankara, Turkey
Eskisehir Osmangazi University-Cardiology ( Site 2510)
🇹🇷Eskisehir, Turkey
Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 2522)
🇹🇷Kayseri, Turkey
Kocaeli Üniversitesi-Cardiology ( Site 2516)
🇹🇷Kocaeli, Turkey
Barts Health NHS Trust-William Harvey Clinical Research Centre ( Site 4001)
🇬🇧London, England, United Kingdom
Royal Free Hospital ( Site 4000)
🇬🇧London, England, United Kingdom