EUCTR2019-001542-17-FI进行中（未招募）1 期
Effect of xenon on brain injury, neurological outcome and survival in patients after aneurysmal subarachnoid hemorrhage - Xe-SAH
Timo Laitio0 个研究点目标入组 160 人开始时间: 2020年7月8日最近更新:
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 160
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1. Aneurysmal subarachnoid hemorrhage visible on CTA or DSA.
- •2. Hunt-Hess 3-5
- •3. Age of = 18 years
- •4. Intubated.
- •5. GCS 3–12 obtained off neuromuscular blocking agents
- •6. Xenon treatment started within 6 hours after onset of SAH symptoms
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 140
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 20
排除标准
- •1.Acute traumatic brain injury
- •2.Maximum diameter of intracerebral hemorrhage > 2.5 cm
- •3.Pneumothorax or pneumomediastinum,
- •4.Acute lung injury requiring = 60% FIO2 (fraction of inspired oxygen).
- •5.Systolic arterial pressure < 80 mmHg or mean arterial pressure < 60 mmHg for over 30 min period
- •6.Bilaterally fixed and dilated pupils
- •7.Positive pregnancy test, known pregnancy, or current breast-feeding
- •8.Chronic neurological deficiency due to chronic traumatic brain injury or other neurological illness
- •9.Imminent death or current life-threatening disease
- •10.Current enrollment in another interventional study
- •11.The subject is known to have a clinically significant laboratory abnormality, medical condition (such as decompensated liver disease or severe chronic obstructive pulmonary disease), or social circumstance that, in the investigator’s opinion, makes it inappropriate for the subject to participate in this clinical trial.
- •12.Presence of implants or foreign bodies which are not known to be MRI safe
研究者
相似试验
进行中（未招募）
1 期
Effect of xenon on brain injury, neurological outcome and survival in patients after aneurysmal subarachnoid hemorrhageAneyrysmal subarachnoid hemorrhage needing ventilatory care in intensive care unitMedDRA version: 20.0Level: HLTClassification code: 10007962Term: Central nervous system vascular disorders NEC Class: 10029205CTIS2022-500596-32-00Turku University Central Hospital160
招募中
2 期
Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid HemorrhageSubarachnoid Hemorrhage, AneurysmalCerebral InjuryCerebral IschemiaCardiac EventCardiac FailureCerebral InfarctionNCT04696523Turku University Hospital160
已完成
2 期
Effect of Xenon and Therapeutic Hypothermia, on the Brain and on Neurological Outcome Following Brain Ischemia in Cardiac Arrest PatientsIschemic Brain InjuryNCT00879892Turku University Hospital110
已完成
3 期
Neuroprotective Effects of Xenon Treatment in Patients with Cerebral InfarctionIschemic StrokeNCT05335109Negovsky Reanimatology Research Institute40
进行中（未招募）
不适用
Effect of Xenon, in Combination with Therapeutic Hypothermia, on the Brain and on Neurological Outcome following Brain Ischemia in Cardiac Arrest PatientsSydänpysähdyksen jälkeinen globaali iskemiaMedDRA version: 9.1Level: LLTClassification code 10054438Term: IschemiaMedDRA version: 9.1Level: LLTClassification code 10007515Term: Cardiac arrestEUCTR2009-009505-25-FITimo Laitio