Comparing the Effect of Bolus Intravenous Dexmedetomidine Vs Magnesium Sulphate On Onset of Atracurium using a TOF Monitor-A Randomised Controlled Trial
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Time required for TOF value to change from 4 to 0
研究概览
简要总结
•Muscle relaxation is an important component in delivering of anesthesia. Non-depolarizing neuromuscular blocking agents are widely used in maintenance of the neuromuscular relaxation.
•MgSO4, which acts as an antagonist at N-methyl-D-aspartate receptors, has an effect on neuromuscular transmission.
•It potentiates the neuromuscular block produced by nondepolarizing neuromuscular blocking agents.
•Alpha2- adrenergic agonists like Dexmedetomidine potentiate NMBA action by increasing NMBA plasma concentration
•Our goal is to compare the onset of action of Atracurium using a TOF monitor after a bolus of Dexmedetomidine or Magnesium Sulphate during induction and compare with a control group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Grade I and Grade II patients b.
- •Age 18 yrs-60yrs.
- •Elective surgeries.
排除标准
- 未提供
结局指标
主要结局
Time required for TOF value to change from 4 to 0
时间窗: Baseline | After drug changes | Pre intubation | Post intubation
次要结局
- Time required for TOF value to change from 0 to 1(30 mins,45 mins,60 mins)
研究者
Dr.Harshanaa.G
Chettinad Academy of Research and Education