Evaluation Report of the Urea / Urine Creatinine as a Marker of Nutritional Status Predictive of ICU Care Associated Infections
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 309
- 试验地点
- 1
- 主要终点
- Number of infections related to care during stay in intensive care unit
研究概览
简要总结
Malnutrition is defined by an energy supply deficit, protein, macro-molecules or micro-nutrients, resulting from an imbalance between nutrient intakes and metabolic needs of the body. It concerns 40 to 60% of patients upon entry into resuscitation and influences their prognosis. Studies over the past decade have shown that nutritional deficiency increases the morbidity and mortality in intensive care.
Several clinical and biological parameters were evaluated as markers of malnutrition, including the ratio of urea / urine creatinine.
The report would identify patients in a state of malnutrition, to optimize their nutritional care.
This setting is easy to obtain in all patients by simple urine collection unlike other clinical and biological criteria of resuscitation malnutrition assessment.
This ratio of urea / urien creatinine would optimize energy intake of critically ill patients, for which nutritional management methods are widely debated.
详细描述
At present, many clinical studies have shown a link between malnutrition and infectious complications in intensive care particularly because of immune disorders.
Many studies testing different nutritional strategies used as the main criterion infectious complications.
So this is a robust standard, well documented in the literature as a reflection of malnutrition in intensive care, and we also want to use in our study.
In a pilot study in the surgical ICU of the Hotel-Dieu report the urea / creatinine urine as a biomarker of poor outcome of nutritional status in the ICU seems extremely discriminating in predicting the existence of nosocomial infection.
Furthermore the kinetics of the relationship between the intake and the 5th day of resuscitation, also appears to be relevant in predicting the occurrence of nosocomial infection.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 or more
- •Admission in ICU
- •Estimated length of stay superior to 5 days
排除标准
- •pathologies modifying the ratio of urea / urine creatinine: end stage renal disease ( creatinine clearance less than 15 mL / min), Gastrointestinal bleeding, Right ventricular failure
结局指标
主要结局
Number of infections related to care during stay in intensive care unit
时间窗: 5 days after admission
Six infections assessed are: 1. Nosocomial pneumonia and tracheobronchitis 2. urinary infection 3. surgical site infection 4. bacteraemia 5. intra-abdominal infection 6. Infection of the central nervous system
次要结局
未报告次要终点