Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling
试验速览
- 阶段
- 2 期
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- HVLT-R
研究概览
简要总结
This study will generate new information on how to optimise brain targets with ECT stimulation.
详细描述
This study will differentiate the brain regions which are related to the effectiveness of electroconvulsive therapy (ECT) as a treatment, from the brain regions associated with memory impairment, with ECT stimulation. This will be done by 1) testing effects on memory of 4 different forms of ECT, which stimulate the brain differently; 2) in a subset of participants, use computer modelling to assess the pattern of brain stimulation with the 4 forms of ECT, and match these results to memory outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Both participants and the outcome assessor will be blinded.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged ≥18 years; right-handed
- •DSM-5 Major Depressive Episode
- •Prescribed with a course of ECT
排除标准
- •Diagnosis (as defined by DSM-V) of psychotic disorder (apart from Major Depressive Episode with Psychotic features), current drug or alcohol abuse or dependence;
- •ECT treatments in last 3 months from a prior course of ECT;
- •Score <23 on the Montreal Cognitive Assessment Battery (MoCA);
- •Past or current neurological illness or injury, medical illness which may significantly affect neuropsychological function;
- •Inability to give informed consent or comply with study procedures; or
- •Not having worked or studied in an English speaking background (to ensure validity of neuropsychological testing).
- •Not be claustrophobic (if having an MRI brain scan).
- •Not have any metal in your head or body (if having an MRI brain scan).
- •Likely non response to RUL forms of ECT, as indicated by past non response to RUL ECT
研究组 & 干预措施
Brief Temporoparietal ECT
Brief Pulse Temporoparietal ECT
干预措施: Brief Temporoparietal ECT (Procedure)
Ultrabrief Temporoparietal ECT
Ultrabrief Pulse Temporoparietal ECT
干预措施: Ultrabrief Temporoparietal ECT (Procedure)
Brief Frontoparietal ECT
Brief Pulse Frontoparietal ECT
干预措施: Brief Frontoparietal ECT (Procedure)
Ultrabrief Frontoparietal ECT
Ultrabrief Pulse Frontoparietal ECT
干预措施: Ultrabrief Frontoparietal ECT (Procedure)
结局指标
主要结局
HVLT-R
时间窗: Approximately 30 min after ECT treatment
Hopkins Verbal Learning Test-Revised
BVMT-R
时间窗: Approximately 30 min after ECT treatment
Brief Visual Memory Test-Revised
次要结局
未报告次要终点
研究者
Colleen Loo
Professor
The University of New South Wales