Mechanism of Action of Electroconvulsive Therapy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Changes in Functional Connectivity of Key Nodes
Study Overview
Brief Summary
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
Detailed Description
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a full course of ECT and clinical measures for depression severity and memory will be obtained at the same times.The project has the following aims and hypothesis: (1) to determine the therapeutic antidepressant mechanism of action of ECT at the circuit level (2) to determine the mechanism of action of iatrogenic amnesia caused by ECT at the circuit level (3) to study the use of fcMRI as a state biomarker for depression (4) to study the use of fcMRI as a predictor of response for depression.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Males and Females Between Ages of 18 and 65
- •Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II
- •Requiring ECT Treatment as Part of Psychiatric Care
Exclusion Criteria
- •Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia
- •History of Psychosis
- •Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months
- •Severe or Unstable Medical Illness
- •Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
Outcomes
Primary Outcomes
Changes in Functional Connectivity of Key Nodes
Time Frame: Through Treatment Completion, Average of 2 Months
Measured by Magnetic Resonance Imaging, Key Nodes include Subgenual Cingulate, Dorsal Anterior Cingulate, Nucleus Accumbens, Hippocampus, Amygdala and Dorsolateral Prefrontal Cortex
Secondary Outcomes
- Changes in Functional Connectivity of Memory Circuits(Through Treatment Completion, Average of 2 Months)
Investigators
Joan A Camprodon, MD MPH PhD
Chief of Division of Neuropsychiatry, Director of TMS Clinic, Director of Lab for Neuropsychiatry and Neuromodulation
Massachusetts General Hospital